Protein Alignment NHERF2 and nherf2

DIOPT Version :10

• Sequence 1: XP_054170405.1
• Gene: NHERF2 / 9351
• HGNCID: 11076
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_001135534.1
• Gene: nherf2 / 100216077
• XenbaseID: XB-GENE-481282
• Length: 348
• Species: Xenopus tropicalis
• Alignment Length: 372
• Identity: 216/372 - (58%)
• Similarity: 271/372 - (72%)
• Gaps: 39/372 - (10%)

Human     3 APEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
            |.|..|||||.:.|||||||||||||||:.||:||:||||||||||.|:||||::||||.|||.|
 Frog     2 AQERHRPRLCHIKRGEQGYGFHLHGEKGKSGQYIRKVEPGSPAEAAGLKAGDRVLEVNGDNVEKE 66

Human    68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQL-TCTEEMAQRGLPPAHDP--------WEPKP 123
            |||||||||||:|.:|||||||:||||.|::... :.||.......|....|        |:.|.
 Frog    67 THHQVVQRIKAIENETRLLVVDRETDEYLKKSPPGSPTESQPNSSAPSTPTPGSNNNGEVWKTKE 131

Human   124 DWAHT----GSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSP 184
            |.:|.    .:||:|.||:|::|.::|..||||:|:|||.||||||||:||||||:|||||||||
 Frog   132 DTSHEDQLHNNHSTENGKQDMNGQVKERCPRLCYLKKGPSGYGFNLHSEKSRPGQFIRSVDPGSP 196

Human   185 AARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVE 249
            ||::|||.||||:||||||:|.::|:||||:||::::|.:|||:|.|||::||:|.:.|||.|.:
 Frog   197 AAKAGLRPQDRLVEVNGQNIENMKHSEVVANIKSKDNETKLLVIDQETDDYFKKLGIAPTEAHGK 261

Human   250 GPLPSPVTNGTSPAQLNG-GSACSSRSDLPGSDKDTEEGPPSGVWDQGSLQTPHPPCSPQDGSAW 313
            |.:  |:|||.:|.|||| .|..||.|||...|||:                       |.|...
 Frog   262 GTI--PLTNGVTPTQLNGDSSTSSSHSDLQSPDKDS-----------------------QAGDLI 301

Human   314 KQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 360
            ::|||:||||.||||||||||||:|.|.|||||||||::|.||||||
 Frog   302 RKDPFEESGLRLSPTAAEAKEKAKAKRANKRAPQMDWSKKHEIFSNF 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NHERF2	XP_054170405.1	PDZ_NHERF-like	10..89	CDD:467249	62/78 (79%)
		PDZ_NHERF-like	150..229	CDD:467249	57/78 (73%)
		EBP50_C	232..360	CDD:462654	65/128 (51%)
nherf2	NP_001135534.1	PDZ_NHERF-like	9..88	CDD:467249	62/78 (79%)
		PDZ_NHERF-like	162..241	CDD:467249	57/78 (73%)
		EBP50_C	244..348	CDD:462654	65/128 (51%)