Protein Alignment TAOK2 and GIN4

DIOPT Version :10

• Sequence 1: XP_011544284.1
• Gene: TAOK2 / 9344
• HGNCID: 16835
• Length: 1242
• Species: Homo sapiens
• Sequence 2: NP_010795.3
• Gene: GIN4 / 852119
• SGDID: S000002915
• Length: 1142
• Species: Saccharomyces cerevisiae
• Alignment Length: 972
• Identity: 186/972 - (19%)
• Similarity: 352/972 - (36%)
• Gaps: 283/972 - (29%)

Human     4 GGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYS-GKQSN 67
            |....::||..:.       |.||...|   |.||.|.|..||:....:..|:|.:|.: ....|
Yeast     5 GNSIPAIKDNTIG-------PWKLGETL---GLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGN 59

Human    68 EKWQDII-------------KEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEV 118
            .....|:             :|:..::.|.|||.::....:......:||:||. .|...:|| |
Yeast    60 VSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLL-V 123

Human   119 HKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---N 180
            .:.||.|.|........:.|::|.|:..::|||:|..|:||.....:|:.|||.|::....   .
Yeast   124 ERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLE 188

Human   181 SFVGTPYWMAPEVILAMDEGQYDG-KVDVWSLGITCIELAERKPPL--FNMNAMSALYHIAQNES 242
            :..|:|::.|||::..:   .|.| ..||||.|:....|...:.|.  .:.|..:.|..:.:.|.
Yeast   189 TSCGSPHYAAPEIVSGI---PYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEF 250

Human   243 PVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNL 307
            .:......|...::.:...|...|:.|..:..:|||  .|.::.|::      |...::|.|
Yeast   251 EMPSDDEISREAQDLIRKILTVDPERRIKTRDILKH--PLLQKYPSI------RDSKSIRGL--- 304

Human   308 QYRKMKKILFQEAPNGPGAEAPEEEEQPTPCSQE----------------------------AEP 344
                                 |.|:...||.|:.                            .||
Yeast   305 ---------------------PREDTYLTPLSESNSSIDATILQNLVILWHGRDPEGIKEKLREP 348

Human   345 YMHRAGTLTSL------------------ESSHSVPSMSISASSQSSSV-------NSLADASDN 384
            ..:...||.:|                  :...|:.|:|:|.|.:.|:.       .||...:.:
Yeast   349 GANAEKTLYALLYRFKCDTQKELIKQQQVKKRQSISSVSVSPSKKVSTTPQRRRNRESLISVTSS 413

Human   385 EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPP 449
            .::.                    :...:.|.:|.||.....|||.......:..:...|.:...
Yeast   414 RKKP--------------------ISFNKFTASSASSSNLTTPGSSKRLSKNFSSKKKLSTIVNQ 458

Human   450 AAPAPTSTTSSA--------RRRAYC-----RNRDHFATIRTASLVSRQIQEHEQDSALREQLSG 501
            ::|.|.|....|        ::||..     :|:....:|:..||    |...:::|...:.:|.
Yeast   459 SSPTPASRNKRASVINVEKNQKRASIFSTTKKNKRSSRSIKRMSL----IPSMKRESVTTKLMST 519

Human   502 YKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQA 566
            |.::......:.:..|::   ....:.|.|..|:      |..|..:..|:.:...|::.|.|:|
Yeast   520 YAKLAEDDDWEYIEKETK---RTSSNFATLIDEI------FEYEKYEQIRKEKEELERKVREAKA 575

Human   567 EERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKE-------ELQENPSTPKREKAEWLLR-- 622
            .|...::....::|:....|||  |...|.::|:||:       :|::..|..|.||.:..:|
Yeast   576 REELERRRRKQEEKERARKLLE--KEDLKRKQEELKKQIEIDISDLEQELSKHKEEKLDGNIRSI 638

Human   623 ------QKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLL----REDLN--- 674
                  :::.:...:.:.: .:|||:.  |.||.|...|        ||..::    .|:::
Yeast   639 SAPMENEEKNINHLEVDID-NILRRRN--FSLQTRPVSR--------LDPGIMFSSPTEEVSPVE 692

Human   675 KKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKH 739
            .|:|:.:          ..|.|.::  |:.::|::.          ||:  .:|..:|.:|.:
Yeast   693 PKRTENE----------RLTTEKKI--LETIRRSKF----------LGS--SFNIDKELKLSK-- 731

Human   740 AAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVG 804
                                   :..|..:.|                :.:.::|::.:..:..
Yeast   732 -----------------------MEYPSIIAP----------------QRLSEERVVSDSNDGY- 756

Human   805 ERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQER 866
            |..||.|:|       ..:...:....:.:|...|.|         .:|.|:|||....:.|
Yeast   757 ESLILPKDG-------NGVSQLKDSTATTAPVSDGRL---------RKISEIRVPQFTRKSR 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	78/327 (24%)
		Smc	<474..>810	CDD:440809	61/357 (17%)
GIN4	NP_010795.3	Protein Kinases, catalytic domain	17..289	CDD:473864	72/287 (25%)
		Kcc4p_like_C	1026..1139	CDD:213379