DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAOK2 and hpo

DIOPT Version :9

Sequence 1:	XP_011544284.1	Gene:	TAOK2 / 9344	HGNCID:	16835	Length:	1242	Species:	Homo sapiens
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	210/784 - (26%)
Similarity:	328/784 - (41%)	Gaps:	182/784 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    10 LKDPDVAE--LFFK----------DDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYS 62
            :|.|:::.  .|||          ..|||:|..:.::|.||:|:||.|....:|.:||||.:..
  Fly    12 MKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV- 75

Human    63 GKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEV 126
                .....:||||:..:|:...|..::|.|.|.:::..|:.|||| .||.||::.:.||.|.|.
  Fly    76 ----ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTED 136

Human   127 EIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPY 187
            |||.:....||||.|||....||||:||.||||:..|..||.|||.|    ..||..|:.:|||:
  Fly   137 EIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPF 201

Human   188 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL-QSGHWS 251
            |||||||   :|..||...|:||||||.:|:||.|||...::.|.|::.|.|...|.. :...||
  Fly   202 WMAPEVI---EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWS 263

Human   252 EYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKIL 316
            ..|.:||..||.|.|.||.|:..||:|.|:...:..:::..:::.| .|:||    |.|..:..
  Fly   264 TEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEET-CAIRE----QQRANRSF- 322

Human   317 FQEAPNGPGAEAPEEEEQPTPCSQEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADA 381
                                            .|.|               |:||:.|:.:
  Fly   323 --------------------------------GGVL---------------AASQAKSLAT---- 336

Human   382 SDNEEEEEEEEEEEEEEEG---PEAREMAMMQEGEHTVTSHSS---IIHRLPGSDNLYDDPYQPE 440
            .:|..::...:....|:.|   ||       :.||:..:|.|.   |.|...|.|         |
  Fly   337 QENGMQQHITDNAFMEDPGTLVPE-------KFGEYQQSSASDATMIAHAEQGVD---------E 385

Human   441 ITPSP-----LQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLS 500
            .|..|     |...||||..|:.:|.......   |....:...|.:...:...:.|.:...:.:
  Fly   386 GTLGPGGLRNLSKAAAPAAASSAASPLDMPAV---DSGTMVELESNLGTMVINSDSDDSTTAKNN 447

Human   501 GYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEK-LARRHQAIGEKEARAA 564
            ..::.|.:::.|.|           ||       .:.:.||.|...|| :|        .|...|
  Fly   448 DDQKPRNRYRPQFL-----------EH-------FDRKNAGDGRGDEKPIA--------TEYSPA 486

Human   565 QAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQ 629
            .||:::.||                       :::|.:::.:::.::...:...|....:.|.||
  Fly   487 AAEQQQQQQ-----------------------QQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQ 528

Human   630 CQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECA-------LL 687
            ..|..:.||.:.|:|...|.......:.|:|.::....||..  .....|:.:..|       ..
  Fly   529 ISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSN--AAPMGQQGIPAAAPAQPPPAY 591

Human   688 LRQHEATR-------ELELRQLQAVQRTRAELTRLQHQTELG-NQL--EYNKRREQELRQKHAAQ 742
            ..||..|:       |.|..:..........|..:.|:.||. .||  :||.:|:..:...:|.:
  Fly   592 QNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKR 656

Human   743 VRQQ 746
            .|||
  Fly   657 KRQQ 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	125/324 (39%)
TAOK2	XP_011544284.1	S_TKc	28..281	CDD:214567	111/258 (43%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	114/262 (44%)
		S_TKc	42..293	CDD:214567	111/258 (43%)
		Mst1_SARAH	608..655	CDD:288481	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910