DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TGM5 and Tg

DIOPT Version :9

Sequence 1:	NP_963925.2	Gene:	TGM5 / 9333	HGNCID:	11781	Length:	720	Species:	Homo sapiens
Sequence 2:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	242/748 - (32%)
Similarity:	362/748 - (48%)	Gaps:	87/748 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     5 LEVALTDLQSSRNNVRHHTEEI----TVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGP 65
            |.|...||....|:..|||...    ..:.|:||||:.|.|.::| ||.:.|..|.|.|
  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISF------ 111

Human    66 LPDLALGTRAVFSLARHHSPSP----------------------WIAWLETNGATSTEVSLCAPP 108
                      :|::|....|||                      |.|.:|::...:..|.:..|.
  Fly   112 ----------IFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPS 166

Human   109 TAAVGRYLLKIHIDSFQGSVTAYQLG-EFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGS 172
            |..|..:.|.|..........:|.|. ...:|||||||:|.|||:...||:||||:|...|::||
  Fly   167 TCPVTEWKLDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGS 231

Human   173 KNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGV 237
            .|.:||..|..||||..:::..||:|.      |......|.||.||.|:|.:.|::||.||:||
  Fly   232 YNRLRPSVWKIGQFERHVLECSLKVLG------TVGRIPPAYRGDPVRVARALSALVNSVDDDGV 290

Human   238 LNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNF 302
            |.|||||:::.|..|.:|||||.||:|:..|. :.|::.|||.|:.|:.|:.|.||||:|:||.:
  Fly   291 LLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCY 354

Human   303 DSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDL----PPAYGGWQVLDATP 363
            .|.|||..:|.:|.:.|...:.|..:..|:|||:|||||.||.|.||    ...:.||||:||||
  Fly   355 SSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATP 419

Human   364 QEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKE--QKLHQDTSSVGNF 426
            ||.|:.:|..|||||.|:|.|::...:|..|||:.||||.:.|...|..:  :.|.:||.::|:.
  Fly   420 QEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHL 484

Human   427 ISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSP 491
            ||||::...||:|||:.||:.|.|.:||...||||:    :|.|...|
  Fly   485 ISTKAVLKWEREDITDTYKHAERSEEERSTMLKALK----QSRHAFSR----------------- 528

Human   492 RSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLKV-NLSAQSLLHDGSPL 555
                  .....:...:....:|.|...:||....||...|.|.....:.. .:|..::|:.|...
  Fly   529 ------YYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGA 587

Human   556 SPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSYP 620
            .........:.|.||.:.....::.:.:|...||:....:|||..:.|.:...........:..|
  Fly   588 VEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKP 652

Human   621 SITINVLGAAVVNQ-PLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQASIIL 684
            .|...:..||:|.| .|.:.:...|||...:...|.||||.|: ::..|..:..:.....|:...
  Fly   653 DIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGI-EQPLKFKIAEIPVGGTAAATF 716

Human   685 ETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVD 717
            :..|..:|:..:.|...|.:..|:.|||:..::
  Fly   717 KYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGM5	NP_963925.2	Transglut_N	4..121	CDD:307149	36/141 (26%)
		TGc	270..363	CDD:214673	43/96 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..499		2/28 (7%)
		Transglut_C	507..606	CDD:307191	21/99 (21%)
		Transglut_C	620..717	CDD:307191	26/97 (27%)
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	35/139 (25%)
		TGc	324..419	CDD:214673	43/94 (46%)
		Transglut_C	538..644	CDD:279295	21/105 (20%)
		Transglut_C	652..750	CDD:279295	26/99 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5146
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41720
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920