DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CD22 and Cd22

DIOPT Version :10

Sequence 1:NP_001762.2 Gene:CD22 / 933 HGNCID:1643 Length:847 Species:Homo sapiens
Sequence 2:XP_006539552.1 Gene:Cd22 / 12483 MGIID:88322 Length:879 Species:Mus musculus


Alignment Length:872 Identity:522/872 - (59%)
Similarity:637/872 - (73%) Gaps:31/872 - (3%)


- Green bases have known domain annotations that are detailed below.


Human     1 MHLLGPWLLLLVLEYLA---FSDSSKWVFEHPETLYAWEGACVWIPCTYRA--LDGDLESFILFH 60
            :|.|  | |||:|.::|   :|.::.|..:||:||:||||||:.|||.|:.  ....|::.:||.
Mouse    14 VHYL--W-LLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQ 75

Human    61 NPEYNKNTSKFDGTRLYESTKDGKVP------SEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGL 119
            |.|::|.|.||.||.||.:||..|.|      |:|.||.|||::..||||.|||:..||||.|||
Mouse    76 NYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRANDSGNLGL 140

Human   120 RMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMR 184
            ||.:.||:|||.|||||||:||.|:||:|.||:|||.|||||.|||||:||.|.|:|.||...:.
Mouse   141 RMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFGYDILLKWFLEDSEIT 205

Human   185 QAAVTSTSLT------IKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK 243
            ....:.||:|      ||:|:|.|:|.|.|:|:.|||.|.||:|.: .|.||..||:|:||:|||
Mouse   206 SITSSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHS-SKVLSERTVRLDVKYTPK 269

Human   244 LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT--VSWLKDGTSL------KKQNTFTLNLREVT 300
            |||||.|::  |.:.:||||||.|:||||:..|  |||.|||..|      ::|....|.|..||
Mouse   270 LEIKVNPTE--VEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVT 332

Human   301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
            ||..|||.||.|||:|||.||||.|.|.||||||.|.|..|||.||..||.:|.|||:|..||||
Mouse   333 KDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYT 397

Human   366 WYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPM 430
            ||||.|.:.|.|:||:.|||:.|||||.|||:|||.||.|:....|:|||.|.||.||||||:..
Mouse   398 WYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFT 462

Human   431 PIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWAS 495
            ||.|||:|||.|.||||||.||.|.|.|.|:......|||:||.|.||:..::|||||..||||.
Mouse   463 PILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWAL 527

Human   496 PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS 560
            ||.|||.||||||:|.|:.|.|||.:|..|.|||||:.|:|.||:|||:|||.|:.:...|:|.|
Mouse   528 PVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGS 592

Human   561 ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVS 625
            :||||:|:|:|.||||||:|.|:||.|:|||||||||||:||||.|||||.|||:||||||||:|
Mouse   593 VSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPIS 657

Human   626 HYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAV 690
            .|||||.:.|.|....|||||||::|||:|:|.|:|||.:|.|.||.|||||||||||||:|||:
Mouse   658 QYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVAL 722

Human   691 GLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPM 755
            |||.||.|.||||.|:|:|::||:.:||||||||||||||||||||.||.||||||.|.|||||.
Mouse   723 GLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPA 787

Human   756 MEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGI 820
            |:|.:||..|||||.:...||||.:...|.|||:..|:||||.:.||.:||||||.|..||||.|
Mouse   788 MDDTVSYAILRFPESDTHNTGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESI 852

Human   821 HYSELIQFGVGERPQAQENVDYVILKH 847
            |||||:|||.|:||||:|:||||.|||
Mouse   853 HYSELVQFGAGKRPQAKEDVDYVTLKH 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CD22NP_001762.2 IgV_CD22_d1 24..137 CDD:409523 64/120 (53%)
FR1 24..47 CDD:409523 14/22 (64%)
Ig strand A 24..28 CDD:409523 1/3 (33%)
Ig strand A' 31..35 CDD:409523 2/3 (67%)
Ig strand B 37..48 CDD:409523 7/10 (70%)
CDR1 48..54 CDD:409523 0/7 (0%)
Ig strand C 54..61 CDD:409523 2/6 (33%)
FR2 55..61 CDD:409523 2/5 (40%)
CDR2 62..89 CDD:409523 14/32 (44%)
Ig strand C1 63..66 CDD:409523 1/2 (50%)
Ig strand C2 69..73 CDD:409523 2/3 (67%)
Ig strand C' 77..80 CDD:409523 1/2 (50%)
FR3 90..123 CDD:409523 21/32 (66%)
Ig strand D 91..95 CDD:409523 2/3 (67%)
Ig strand E 100..108 CDD:409523 5/7 (71%)
Ig strand F 115..123 CDD:409523 6/7 (86%)
CDR3 124..126 CDD:409523 0/1 (0%)
FR4 127..137 CDD:409523 7/9 (78%)
Ig strand G 127..137 CDD:409523 7/9 (78%)
IgC1_CD22_d2 141..238 CDD:409532 52/102 (51%)
Ig strand A 143..148 CDD:409532 3/4 (75%)
Ig strand B 156..164 CDD:409532 5/7 (71%)
Ig strand C 172..178 CDD:409532 3/5 (60%)
Ig strand C' 180..183 CDD:409532 0/2 (0%)
Ig strand D 188..194 CDD:409532 2/5 (40%)
Ig strand E 198..207 CDD:409532 4/8 (50%)
Ig strand F 215..223 CDD:409532 4/7 (57%)
Ig strand G 228..236 CDD:409532 4/7 (57%)
IgC2_CD22_d3 242..329 CDD:409531 52/94 (55%)
Ig strand A 242..249 CDD:409531 6/6 (100%)
Ig strand A' 253..257 CDD:409531 1/3 (33%)
Ig strand B 258..268 CDD:409531 6/9 (67%)
Ig strand C 275..281 CDD:409531 4/7 (57%)
Ig strand C' 283..286 CDD:409531 1/2 (50%)
Ig strand E 292..298 CDD:409531 2/5 (40%)
Ig strand F 305..313 CDD:409531 5/7 (71%)
Ig strand G 316..329 CDD:409531 9/12 (75%)
Ig_3 335..400 CDD:464046 39/64 (61%)
Ig 499..591 CDD:472250 55/91 (60%)
Ig strand B 525..529 CDD:409531 2/3 (67%)
Ig strand C 540..544 CDD:409531 2/3 (67%)
Ig strand E 555..558 CDD:409531 1/2 (50%)
Ig strand F 568..573 CDD:409531 2/4 (50%)
Ig strand G 582..585 CDD:409531 1/2 (50%)
IG_like 606..677 CDD:214653 47/70 (67%)
Ig strand B 612..616 CDD:409531 3/3 (100%)
Ig strand C 626..630 CDD:409531 2/3 (67%)
Ig strand E 642..646 CDD:409531 3/3 (100%)
Ig strand F 656..661 CDD:409531 2/4 (50%)
Ig strand G 670..673 CDD:409531 2/2 (100%)
ITIM motif 1 760..765 2/4 (50%)
ITIM motif 2 794..799 4/4 (100%)
ITIM motif 3 820..825 4/4 (100%)
ITIM motif 4 840..845 4/4 (100%)
Cd22XP_006539552.1 Ig 37..158 CDD:472250 64/120 (53%)
Ig strand B 53..57 CDD:409523 1/3 (33%)
Ig strand C 70..74 CDD:409523 0/3 (0%)
Ig strand E 123..127 CDD:409523 3/3 (100%)
Ig strand F 137..142 CDD:409523 3/4 (75%)
Ig strand G 150..153 CDD:409523 2/2 (100%)
Ig 162..264 CDD:472250 52/102 (51%)
Ig strand B 178..182 CDD:409532 3/3 (100%)
Ig strand C 194..198 CDD:409532 1/3 (33%)
Ig strand E 229..233 CDD:409532 2/3 (67%)
Ig strand F 243..248 CDD:409532 2/4 (50%)
Ig strand G 257..260 CDD:409532 0/2 (0%)
Ig 268..361 CDD:472250 52/94 (55%)
Ig strand B 285..289 CDD:409531 3/3 (100%)
Ig strand C 300..306 CDD:409531 3/5 (60%)
Ig strand E 318..328 CDD:409531 2/9 (22%)
Ig strand F 338..343 CDD:409531 3/4 (75%)
Ig strand G 352..355 CDD:409531 2/2 (100%)
Ig_3 375..432 CDD:464046 35/56 (63%)
Ig 451..>493 CDD:472250 28/41 (68%)
Ig strand B 470..474 CDD:409531 3/3 (100%)
Ig strand C 485..489 CDD:409531 1/3 (33%)
IG_like 550..621 CDD:214653 41/70 (59%)
Ig strand B 557..561 CDD:409531 2/3 (67%)
Ig strand C 572..576 CDD:409531 2/3 (67%)
Ig strand E 586..590 CDD:409531 1/3 (33%)
Ig strand F 600..605 CDD:409531 2/4 (50%)
Ig strand G 614..617 CDD:409531 1/2 (50%)
IG_like 637..709 CDD:214653 47/71 (66%)
Ig strand B 644..648 CDD:409353 3/3 (100%)
Ig strand C 658..662 CDD:409353 2/3 (67%)
Ig strand E 674..678 CDD:409353 3/3 (100%)
Ig strand F 688..693 CDD:409353 2/4 (50%)

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