|
Human 6 NNNP-----------------GGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKHKGYSPPESRKSN 53
||.| .|..:|:..:..||.| ..||. .|..:|.||
Fly 517 NNTPAVAAASTIKATTTATTSSGYQQRAAPHGQGAAP---GAGGG-----------GPRATRSSN 567
Human 54 SKAPKVQSNTTSELS-RGHLSKRSCSSSSAVI---------VPQPEDPDRANTSERQKTGQVPKK 108
|.: ||...:.| ..||:..:.::..|:. .|||....:....::|:..|:...
Fly 568 SNS----SNNVVDYSIMPHLTTVATTTPHALTPQQHQQQRQPPQPPSHQQQQVHQQQQPPQLLPT 628
Human 109 DNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQQLKSAQSPSTS 173
.....:....:|......:.::|..|.| ...:.....:.|.:.:.:| |:|.::.||:|...
Fly 629 HQFAHLSSFVTPTAAAAAAAAAAHYPPA--SAAAAYFAQQQHHQHQHQH--QQQHVQQAQAPQPH 689
Human 174 KAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKP--TKLASKSATSA-------- 228
..|: |.:...:........:|:| ......::.|.| |:....:||:|
Fly 690 YYHS--------SVAVLHQPPPHHFTSTGAG-PPPALFQQQAPPQLTRYTPATATTAATFVPPQQ 745
Human 229 --------KAGCSTITDSSSAASTSSSSSAVA-------------SASSTV------PPG----- 261
:...|::..||...:.|..|||.| ||::.| |||
Fly 746 QQVVYNPQQQQHSSLRRSSRGKTGSCVSSAAAAQQQQHHQQQQHSSAAAAVQQQLLPPPGTYQYQ 810
Human 262 ----------ARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSL-- 314
.|.:|...|.:.::.:.|.....::...:::|.:...... :...:.:|
Fly 811 QVGGNTVVVAVRHQQQLQQQQQQQQQLALHHQHQQQQHQQQQQQHQQQQH-----QQQQRATLVQ 870
Human 315 PKTKLSLPGSSKSETSKP------GPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTG- 372
|....|...:...:..:| ||....:..||...:....::.||:..| ....:|.|.|
Fly 871 PGFLFSYRSNQPQQQQQPAQQIHQGPKVTHSSAASDALTYSLMAQQPPSGPP--HAGGQQITPGA 933
Human 373 --------SCASTSRRGSGLGKRGAAEA----RRQEKMADPESNQEAVNSSAARTDEAPQGAAAS 425
:.|.::.|..|.|..|...| ......|....|..||.:|::....|.|.|:::
Fly 934 NSANLSIVAAALSAARDVGGGSDGGGSAGGATPATGASASSVGNTSAVGASSSSNSSAGQAASSN 998
Human 426 SSVAGAVGM------------TTSG-------------ESESDDSEMGRLQALLEARGLPPHLFG 465
|:...|.|. |||| :|||||||:||||||||||||||||||
Fly 999 SNNVTATGSGSAPGGGPTSTGTTSGTQHGSGSGAAAAVDSESDDSEVGRLQALLEARGLPPHLFG 1063
Human 466 PLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVV 530
.||||::.:.|||||:.:||||.|||||||:.||||||||.|||||:||||||:||.|||:|.||
Fly 1064 ALGPRVTHILHRTIGNSSSSKANQLLQGLQSHDESQQLQAAIEMCQMLVMGNEDTLAGFPIKQVV 1128
Human 531 PALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALE 595
||||.||:|||||||||:|||||.||:|||||||..||:|:||||||||||||:|||||:|:|||
Fly 1129 PALIQLLRMEHNFDIMNNACRALAYMLEALPRSSGTVVEAVPVFLEKLQVIQCMDVAEQSLSALE 1193
Human 596 MLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLT 660
:|||||:||||||.|::.||.||:||||.|||.|||||||||.::.|:||||||:|||||.:.|:
Fly 1194 ILSRRHNKAILQANGISACLTYLDFFSIVAQRAALAIAANCCLNMHPEEFHFVAESLPLLARLLS 1258
Human 661 HQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSL 725
.||||.:||.|..|.|||::|||:...|||:||.|||.|.||||:|||.||::|.|..||||.||
Fly 1259 QQDKKCIESVCSAFCRLVESFQHDGQRLQQIASPDLLKNCQQLLLVTPAILNTGTFTAVVRMLSL 1323
Human 726 MCSNCPTLAVQLMKQNIAETLHFLLCGASN--GSCQEQIDLVPRSPQELYELTSLICELMPCLPK 788
||.:||.||:.|::.:||.||.:||.|.:. .:....::|:.|||.||||||.||.||||.||.
Fly 1324 MCCSCPDLAISLLRNDIAATLLYLLTGNAEPAAASATHVELISRSPSELYELTCLIGELMPRLPL 1388
Human 789 EGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGEDEISLSTLGRVYT 853
:||||||::|.:......|...||||||||.||.|:.||||:|| ||:|..||||||||.||.||
Fly 1389 DGIFAVDSLLDRPTLNTQDQVHWQWRDDRGSWHNYSTIDSRLIE-AANQSSEDEISLSTFGRTYT 1452
Human 854 IDFNSMQQINEDTGTARAIQRKPN-----PLA--------------------------------- 880
:||::||||||||||.|.:||:.| |::
Fly 1453 VDFHAMQQINEDTGTTRPVQRRLNHNYVAPMSAGQDLTTTSAGSAAAGGASTSAAAAAASSNNNN 1517
Human 881 --NSNTSGYSESKKD-------DARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLR 936
|:|..|.|.:... |||...:||:..||..|||.:|.||||||||||||.||:||||
Fly 1518 NNNNNPPGNSVNLNQVKRRPSLDARIACLKEERGLAADFIKHIFNVLYEVYSSSAGPNVRYKCLR 1582
Human 937 AILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREG 1001
|:||::|:|..|||:.|||...||||||.||.|.||:|||||||||||||::|||:|..:|||||
Fly 1583 ALLRMVYYATPELLRQVLKYQLVSSHIAGMLGSNDLRIVVGALQMAEILMRQLPDVFGTHFRREG 1647
Human 1002 VMHQVKHLAESESLL-----------TSPPKACTNGSGS--------------MGSTTSVSSGTA 1041
|::|...|.:..:.: |:.|.|...||.| |.|...:||.:.
Fly 1648 VIYQFTQLTDPNNPICANPSPKPLSATATPTANAGGSQSAPASANSLQVNPFFMDSAPGLSSAST 1712
Human 1042 TAA------------THA-----AADLGSPS---------------------------------- 1055
|.: :|| |:..|:||
Fly 1713 TPSSSKHQSYSVKSFSHAMNALTASAKGTPSGALDATSSSTTAGGYNYSSSAPSSSSGAPAAYFV 1777
Human 1056 --------LQHSRDDSL-------DLSPQG----------------------------------- 1070
..|.:..:: :|.|.|
Fly 1778 TQQGDPRQYVHFQQPAVPAPPPQQELLPSGVQQQGQQVPQVIYQPHHQQPAHLVLASTSSGAASS 1842
Human 1071 ---------------RLSDVLKRKRLPKR----GPRR---------------PKYSPPRDDDKVD 1101
:::|:||||..||| |.|. |..:||.......
Fly 1843 SSSSSSSSSASALQHKMTDMLKRKAPPKRKSQSGGRAKSRQEDAAVAPAGSGPGGAPPSSSGSAM 1907
Human 1102 NQAKSPTTT--------------------------------QSPKSSFLASLNPKTWGRLSTQS- 1133
::..|..|: .|.||||||||||..|||.:.|:
Fly 1908 HELLSRATSLGSGNGGRSTPNSGGGSGSSKSRFNAGNSSNAGSSKSSFLASLNPARWGRQTHQNH 1972
Human 1134 ----------------NSNNIEPARTAGGSGLARAASK--------------------DTISN-- 1160
:|.|.....:..|:|||...|: .:||:
Fly 1973 HHHHQQSQQQHHGLSKDSGNSNSTGSGSGAGLAYTVSQHGAGSGAGGLNAAAVAASISKSISHAN 2037
Human 1161 -----NREKIKGWIKEQAHKFVERYFSSE----------------------NMDGSNP-----AL 1193
|||:.:.|::|||..||:||...| :..|:.| :.
Fly 2038 LLAAANRERARQWVREQAVDFVKRYTEQEAKRSKAASESGATQSGSSGVGLSSTGNTPLSTAGST 2102
Human 1194 NVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSR 1258
|||:||.:...:||.......:.|:|:::|:.|||:|.||:.|||.:|.:|.|:| ||...|.|
Fly 2103 NVLERLSSILFKLNGSYHDCLDALLELKTILLESDISPFEVNHSGLIKAMLNYMT--SETGLVER 2165
Human 1259 EIRLKRFLHVFFSSPLPGEEPIGRVEPVGNAPLL------ALVHKMNNCLSQMEQFPVKVHDFPS 1317
:.||:.|:|||...|| ||: ::.||..|.: |.|.|:|.|::|:|||||||||||:
Fly 2166 DARLRSFMHVFAGLPL---EPL--LQNVGQMPTIEPIAFGAFVAKLNGCVTQLEQFPVKVHDFPA 2225
Human 1318 GNGTGGSFSLNRGSQ-ALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVR 1381
|.| .|.:| ||:|||||||||.|||||.|.|::|||||.|||||||:|||||||||||
Fly 2226 GPG-------GRSNQSALRFFNTHQLKCNLQRHPQCNNLRQWKGGTVKIDPLAMVQAIERYLVVR 2283
Human 1382 GYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQA 1446
|||.:| .||||| |:|::|:::||..|:..:.||:|||.||:|:|||||||||||:|||...
Fly 2284 GYGGIR---ADSDDD-SEEDMDDNVAAVVLSQASFRHKLQFTIGDHVLPYNMTVYQAVKQFSPLV 2344
Human 1447 EDERESTDDESNPLGRAGIWTKTHTIWYKPVRED---------EESNKDCVGGKRGRAQTAPTKT 1502
.::.|:.::....||.|.||.:.|||.|:||.|: ..|:..|..|.:.:..::.:.:
Fly 2345 SEQPETDNESETLLGNASIWVQQHTIHYRPVEEEVTSGAAAGAASSSSSCSSGVQKQQSSSSSAS 2409
Human 1503 SPRNA-----------------------------KKHDELWHDGVCPSVSNPLEVYLIPT-PPEN 1537
|..|| :|..||||:|:.|.|.:.|:.:|..: |.:.
Fly 2410 SCVNATSSCSSSSGVASGGGSLTKKAHKSSSKFMRKKTELWHEGIAPVVISALKPFLSSSLPADV 2474
Human 1538 ITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTGN 1602
:|.:|.|||.:.:|||:||::|:|.:||...:.:.|||.|:||:.|:.|||||||||||||||||
Fly 2475 VTVQDASLDALCMLRVIHALNRHWDHLYGCVVRQNIIPQSDFIHPKIMAKANRQLQDPLVIMTGN 2539
Human 1603 IPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKR 1667
:|.||.::|..|||.|||:||.:|||.|:||||||:||||||.|::|.::|.: ||||||||:||
Fly 2540 LPQWLPQIGMACPFLFPFETRHLLFYATSFDRDRALQRLLDTTPDLNAAESSE-RVAPRLDRRKR 2603
Human 1668 TVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEE-- 1730
.::|.|:|||||.::||.|.|:|:||||||||||||||||||||||||.||||.|||||.|.:
Fly 2604 AISRTEILKQAEHILQDFGHSKALLEIQYENEVGTGLGPTLEFYALVSAELQRTDLGLWNGSDSY 2668
Human 1731 ----VTL---------------------------------------------------------- 1733
||:
Fly 2669 KQNSVTIVDVVKANSAVLHIEDALEATTTDQNTPAVAGASLVSSSTTTTTTTAQQHQHPPTRSSS 2733
Human 1734 -----------------SNPKGSQEG--------------------------------------- 1742
|:..|:.|.
Fly 2734 RSHVLRSGAGQQPVEHSSSSAGANENALNMVIAQQFSDTNSANPAAIDNPSSTTTATTVVQHNTT 2798
Human 1743 ------------TKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLG 1795
|.|:..:.|||.||.|:::|...:.|.|.||:||||.||||:||.|::|||..
Fly 2799 TNNSSIITTTTTTSYVHAVHGLFPLPLGKSSKLPQMTKAKAKFKFLGKFMAKAVMDSRMLDLPFS 2863
Human 1796 LPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNG 1860
||||:|::.:|.|:...||..:.|.|..::..|:|:|||::.:..|.:.........:|.|.::|
Fly 2864 LPFYRWLVSEEHSIGLADLMRVAPEVQNTLVRLQDLVRQREYILSDPNIDAMEKTEKIEQLDLDG 2928
Human 1861 CSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVF 1925
|.:.||||||.|||..||||.:||:|.|||:|||.:|:.||.:|.|.|||.:||::.|:||:|||
Fly 2929 CPIADLGLDFVLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVF 2993
Human 1926 PLSHLQYFYPEELDQLLCGSKAD----TWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQ 1986
|:..|:.||||||:.:.|||.:: .|:.|.|.|.||.|||:..||:|:::|:|||:|::.::
Fly 2994 PIQRLRMFYPEELECVFCGSGSEQQHSRWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDE 3058
Human 1987 QRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMR 2051
||.||||||||||||.|||::|.|||||||||.:..:||:|:||||||||||||||||||.|:||
Fly 3059 QRAFLQFVTGSPRLPTGGFKALTPPLTIVRKTLDENQNPNDYLPSVMTCVNYLKLPDYSSREVMR 3123
Human 2052 EKLLIAAREGQQSFHLS 2068
:||.:||.||..|||||
Fly 3124 QKLKVAANEGSMSFHLS 3140
| 
