DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRIP12 and Ufd4

DIOPT Version :9

Sequence 1:XP_024308991.1 Gene:TRIP12 / 9320 HGNCID:12306 Length:2092 Species:Homo sapiens
Sequence 2:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster


Alignment Length:2368 Identity:538/2368 - (22%)
Similarity:856/2368 - (36%) Gaps:727/2368 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    53 NSKAPKVQSNTTSELSRGHLSKRSCSSSSAVI---VPQPEDPDRAN--------TSERQKTGQVP 106
            :|.:|: ..|.:|| :||...::...:.|.||   |.||..|..:.        ..:.|||.|:.
  Fly   759 SSGSPE-NGNDSSE-NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQ 821

Human   107 KK-------------------DNSRGVKRSAS------PDYNRTNSPSSAKKPKALQHTESPSET 146
            ..                   :::||.|.:.|      ||:  .:..|:|||.:....||.    
  Fly   822 IHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDF--ASGWSTAKKKRNKSKTEG---- 880

Human   147 NKPHSKSKKRHLDQE---QQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSEST 208
                .|.:.|:|.:|   :..||||                             .:..|:.:..|
  Fly   881 ----QKFQVRNLSREIYNKYFKSAQ-----------------------------IIPRGAVAILT 912

Human   209 GAEERSAKPTKLASKSATSAKAGC--STITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQN 271
            ..    .|..:|:.:....|..|.  :|:||:....|.......|.||......|  :.|.....
  Fly   913 DI----VKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSG--LVQALVAV 971

Human   272 KARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKP---- 332
            .:......:||..:|:..:|:                  :||:.| |..|..:.:|.|:||    
  Fly   972 LSVNHWETNSPRCKRNKMQKQ------------------RVSVFK-KCILEDNVESATNKPRTKS 1017

Human   333 GPSGLQAKLASLRKSTKKRS----ESPPA--ELPSLRRSTR-QKTTGSCAST--SRRGSGLGKRG 388
            ..|.|..||.|:.:||:|..    :||..  .|..|::..| :.....|.||  .|.|..|....
  Fly  1018 TASILIQKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEP 1082

Human   389 AA----------------------------EARRQEKMA---------DPESNQEAVNSSAARTD 416
            .|                            :..|:.:.|         |.|.....:.|:|...|
  Fly  1083 LATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCD 1147

Human   417 EAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALL--EARGLPPHL-------FG-PLG--- 468
                  ..:.:..|.|.:|:   ||......|:|:.:|  ::..|..|.       |. .||   
  Fly  1148 ------WVNPAQYGLVQVTS---SEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYI 1203

Human   469 -PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVK----- 527
             |....|.|.. |.|.|:....||||.:.......|...::...|:..|:..|   :|:.     
  Fly  1204 IPTAYTLRHAR-GYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTAT---WPINCATDD 1264

Human   528 SVVPALITLLQMEHNFDIMNHACRALTYM----MEALPRSSAVVVD-----------------AI 571
            ||....|.:.|...|.....|      |:    .|...|...|..|                 .|
  Fly  1265 SVWYRHIRIQQNGRNASGQTH------YLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQI 1323

Human   572 PVFLEKL----QVIQCID--------VAEQALTALEMLSRRHSKAI-------------LQAGG- 610
            ...|:.:    :||:.:|        .||..:|     ...|:..|             :.|.| 
  Fly  1324 RAQLKHMTTGARVIRGVDWRWEEQDGCAEGTIT-----GEIHNGWIDVKWDHGVRNSYRMGAEGK 1383

Human   611 ----LADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTC 671
                |||| .||..|..|....:.:.||.      |.|     .....||.|.:.......|:| 
  Fly  1384 YDLKLADC-EYLSAFDGNQSMGSASTAAK------PSE-----KGGNTLTSRKSSSTPSLPEAT- 1435

Human   672 LCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQ 736
                   :..|:.|....|..|.|.|...|.:..:...:.:|..        :.:.||  .||:.
  Fly  1436 -------EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAK--------TQIISN--QLAMN 1483

Human   737 LMKQNIAETLHFLLCGASNGSCQEQIDLVP-RSP--QELYELTSL--ICELMPCLPKEGIFAVDT 796
            ......|...|     ..:|:.|...|.:. .||  :||..::.|  |...||.:          
  Fly  1484 TSSSREARAKH-----KESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAI---------- 1533

Human   797 MLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGEDEISLSTLGRVYTIDFNSMQQ 861
                 |:.|...                      :...:..:...|:|...:.||.|..:...:.
  Fly  1534 -----NSSNVSD----------------------LATISENLSLTELSKENICRVLTPSYKPAES 1571

Human   862 INEDTGTARAIQRKPNPLAN--SNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSS 924
            :.....::....:..:|..|  .|.|...|:.|.:|...:.|...:|..: ::|         |:
  Fly  1572 VTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLAN-LRT---------SN 1626

Human   925 SAG-PAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDL-----KIVVGALQ--M 981
            .|| |.|......|:..|....|.   .|:::|.:     .|:||:...     .:.||..:  .
  Fly  1627 IAGCPPVTQLSTEALEMIDKMRDG---VDMIRNMS-----NSILSTDTFPVPCTNVPVGGKKTPK 1683

Human   982 AEILMQKLPD----------------------------------IFSVYFRREGVMHQVKHLAES 1012
            |:.|:.  ||                                  :.|:...:|..:.. ::::..
  Fly  1684 AQALIN--PDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISN-ENVSVP 1745

Human  1013 ESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLK 1077
            ..:..|.|...|..:..:.||:.|::.|....|.||.                            
  Fly  1746 SQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAI---------------------------- 1782

Human  1078 RKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTT--TQSPKSSFLASLNPKTWGRLSTQSNSNNIEP 1140
                   ..||........|:::.|...:...  .|:...|||.. :..:..:|:..||.:    
  Fly  1783 -------ARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGH-SVTSLVKLALSSNFH---- 1835

Human  1141 ARTAGGSG-LARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATE 1204
                  || |:.|.|..::|:|                    :|||:..|||             
  Fly  1836 ------SGLLSTAQSYPSLSSN--------------------NSENIAPSNP------------- 1861

Human  1205 QLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVF 1269
                             |..|....|:..|.|:     |.:.|||.|..   |.::.|:.||...
  Fly  1862 -----------------SNTSAGQQSASTINHT-----LTMSLTSTSSD---SEQVSLEDFLESC 1901

Human  1270 FSSPLPG--------------EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGN- 1319
            .:..|.|              ||.....|.|||..|..:|.:  |.|:.|:       |....| 
  Fly  1902 RAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSR--NLLTFMD-------DEAMENR 1957

Human  1320 --GTGGRGSQALKFFNTHQLKCQL---QRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYG 1379
              |...|.|...:|....|....:   ...|...||.|  ...::|.||               |
  Fly  1958 LVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQ--TSDLEISPL---------------G 2005

Human  1380 RVREDDEDSDDDGSDEEIDESLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRL 1444
            ......:.|   |..|.|::.|:               ||.|:...:..|...: ::..|.    
  Fly  2006 AELPKPQQS---GGPETIEQPLL---------------GLKLRGPGIGGIPEVE-IDLSNT---- 2047

Human  1445 QFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDESNPLGR-AGIWTKTHTIWYKPVR-EDEES 1507
                       :.|:::||::. :|.        .:.|.|.: ..||..|:||.|:.|. |.:||
  Fly  2048 -----------DWTIFRAVQEL-LQC--------SQLNKLDKFRKIWEPTYTIVYREVSPEAQES 2092

Human  1508 NKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTPPENITFE--DPSL- 1569
            .  |:..:. ..|| |..:|...|..                    |.|..|.:|.|.  |.:| 
  Fly  2093 T--CLESEE-FPQT-PDVSSKSGAST--------------------LSPNSPMHIGFNVADNNLC 2133

Human  1570 ---DVILLLRVLHAISRYWYYLYDNAMCKE----IIPTSEFINSKLTAKANRQLQDPLVIMTGNI 1627
               ||:.||..::.:::...    ::..||    ::....||:.|:|.|..:|:|||||:.:..:
  Fly  2134 SVDDVLELLTQINGLNQSEI----DSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNAL 2194

Human  1628 PTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAM-------------QRLLDTNPEINQSDSQD 1679
            |.|...|.::|||.|||:|||:.|..|:|...|::             ||:...:|   :.|..:
  Fly  2195 PNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSP---RRDDHE 2256

Human  1680 SRVAPRLDRKKRTVNR-EELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQ 1743
            .|:. ||..::..|.| |:||..|..||:...:.:::||:::.:|.||||||||||||||:.|:|
  Fly  2257 FRIG-RLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQ 2320

Human  1744 RADLGLW-----RGEEVTLSNPKGSQEGTK-----YIQNLQ-GLFALPFGRTAKPAHIAKVKMK- 1796
            |:||.:|     .||:.  .|...|.||..     |:...: |:|..|..:.::   |.:..:| 
  Fly  2321 RSDLCMWLCDDDLGEDT--ENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSE---ICENVLKY 2380

Human  1797 FRFLGKLMAKAIMDFRLVDLPLGLPFYKW------------------------------------ 1825
            |.|.|..:||.:.|.||||:||...|.:.                                    
  Fly  2381 FWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETC 2445

Human  1826 --MLRQETS--------LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQD---KSQTKESLQYAL 1877
              :||.:::        |:..:|.:|||...:.:..:::::.:|:.:|.|   .::.|..|...|
  Fly  2446 TKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINEL 2510

Human  1878 ETLTMNG--CSVEDLGLDFT-LP-----GFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGV 1934
            :..|.||  .|:|||.|.|| ||     |:...||...|..:.|||.|||.|..|::.:.|.:|:
  Fly  2511 KLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGI 2575

Human  1935 SRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFL 1999
            ::|..:|.|||..||||..|..|.|.|...::||.:...|..:.::....|..||..||...:..
  Fly  2576 AQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRF 2640

Human  2000 FEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLK 2064
            ..:|.|...::::.||||.||...||.||..:|:|.||:|||......:    .|||.|||:|||
  Fly  2641 VNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGS----YPSVNTCVHYLK 2701

Human  2065 LPDYSSIEIMREKLLIAAREGQQSFHLS 2092
            ||||.:.|||:|:||.|.:|  :.|||:
  Fly  2702 LPDYPTEEIMKERLLTATKE--KGFHLN 2727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRIP12XP_024308991.1 SR-25 99..>233 CDD:313680 30/163 (18%)
Arm_3 489..>714 CDD:330530 56/280 (20%)
WWE 808..874 CDD:308464 5/65 (8%)
HECTc 1690..2090 CDD:238033 156/469 (33%)
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 29/134 (22%)
MIB_HERC2 1333..1389 CDD:310955 10/60 (17%)
DamX 1576..>1725 CDD:330571 29/168 (17%)
HECTc 2265..2725 CDD:238033 156/470 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3704
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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