Protein Alignment ORAI3 and orai2

DIOPT Version :10

• Sequence 1: NP_689501.1
• Gene: ORAI3 / 93129
• HGNCID: 28185
• Length: 295
• Species: Homo sapiens
• Sequence 2: XP_005165627.1
• Gene: orai2 / 555612
• ZFINID: ZDB-GENE-060531-127
• Length: 281
• Species: Danio rerio
• Alignment Length: 286
• Identity: 159/286 - (55%)
• Similarity: 198/286 - (69%)
• Gaps: 40/286 - (13%)

Human     9 GEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSG 73
            |..||...:.....|...||::|.|.||:|:.::.||::|||||:||||||||||||||||||||
Zfish    24 GSPAPGGSDRLQDGGGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSG 88

Human    74 FAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQS 138
            ||||||||||||..:.||..||:|||.|||||||||||||::|||:||::||||||||||||.:|
Zfish    89 FAMVAMVEVQLEMQYNYPRVLLIAFSVCTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSVSES 153

Human   139 PHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATS 203
            ||:|:|.|:|||||||||||..||||||||:.|:||:|:.
Zfish   154 PHERMHHYIELAWGFSTALGILLFLAEVVLLCWIKFLPVD------------------------- 193

Human   204 LSPASNLPRSSASAAPSQ--AEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHF 266
                |....:||..|..|  :.||..|..:         |||||:|||.|||||||:||.|.:||
Zfish   194 ----SGAQSASALVALKQNCSTPAVQPGHS---------GWQAALASTIIMVPVGLIFVVFTIHF 245

Human   267 YRSLVAHKTDRYKQELEELNRLQGEL 292
            |||||.|||:|:.||:|||::::.:|
Zfish   246 YRSLVRHKTERHHQEIEELHKIKVQL 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI3	NP_689501.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/13 (23%)
		Orai-1	48..276	CDD:462291	138/229 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..238		8/35 (23%)
orai2	XP_005165627.1	Orai-1	63..255	CDD:462291	138/229 (60%)