Protein Alignment ORAI3 and Orai

DIOPT Version :10

• Sequence 1: NP_689501.1
• Gene: ORAI3 / 93129
• HGNCID: 28185
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_001137696.1
• Gene: Orai / 37040
• FlyBaseID: FBgn0041585
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 304
• Identity: 122/304 - (40%)
• Similarity: 165/304 - (54%)
• Gaps: 85/304 - (27%)

Human    12 APLNPEGE--SPAGSA--------TYRE-----FVHRGY-------LDLMGASQHSLRALSWRRL 54
            |||.|...  ||..:|        ||::     |..||:       :...|...||...||||:|
  Fly   243 APLAPLASIASPPFAAQPPPFQLRTYQQNQSYRFQPRGHHRTASSSMSQSGEDLHSPTYLSWRKL 307

Human    55 YLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCL 119
            .||||||||||:||||||||||||||||||:.|...|||:|:||:.|||:|||||:.|||:|||:
  Fly   308 QLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCI 372

Human   120 LPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTP 184
            ||:||.|.|:|:::.||:|||:|||.|:|.||.|||.||..|||.|:.::.||||..:..|
  Fly   373 LPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPP---- 433

Human   185 TPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMAST 249
                                                                       ||.::.
  Fly   434 -----------------------------------------------------------AAWSAC 439

Human   250 AIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQ 293
            .:::||.::|:|||:|||||||:||.:.....:.||..|:.:::
  Fly   440 VVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQME 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI3	NP_689501.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/12 (50%)
		Orai-1	48..276	CDD:462291	104/227 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..238		0/33 (0%)
Orai	NP_001137696.1	Orai-1	301..466	CDD:462291	104/227 (46%)