Protein Alignment ORAI3 and orai-1

DIOPT Version :10

• Sequence 1: NP_689501.1
• Gene: ORAI3 / 93129
• HGNCID: 28185
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_001254835.1
• Gene: orai-1 / 175221
• WormBaseID: WBGene00015648
• Length: 297
• Species: Caenorhabditis elegans
• Alignment Length: 304
• Identity: 94/304 - (30%)
• Similarity: 140/304 - (46%)
• Gaps: 94/304 - (30%)

Human     3 GGEGDAGEQAPLNPEGESPAGSAT----------YREFVHRGYLDLMGASQHSLRALSWRRLYLS 57
            ||....|:..|.:|...| ..:||          :::..|||.|||.....:.          ||
 Worm    63 GGSSSMGQSPPHHPANTS-TNTATHHTLSPVIQCFQQDQHRGELDLSEKYNYD----------LS 116

Human    58 RAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPH 122
            ||:|||||||||||:|||||.:||:|.  |...|..||:.....|::||:|||.|||:|||:||:
 Worm   117 RAQLKASSRTSALLAGFAMVCLVELQY--DQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPY 179

Human   123 IEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPM 187
            :||.      .....|||.:|..|::|:|.|||.:|..|||.|:.::.:|||..:|.|
 Worm   180 MEAT------GCTQDSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYP------- 231

Human   188 VPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIM 252
                                                                   .|...:||::
 Worm   232 -------------------------------------------------------TAGYITTAML 241

Human   253 VPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNR---LQGELQ 293
            ||||:|||.|:...:::.|:|...|:|.:::.:.:   ::..||
 Worm   242 VPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQ 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI3	NP_689501.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/19 (32%)
		Orai-1	48..276	CDD:462291	76/227 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..238		0/33 (0%)
orai-1	NP_001254835.1	Orai-1	108..263	CDD:462291	75/234 (32%)