Protein Alignment ORAI3 and orai2

DIOPT Version :10

• Sequence 1: NP_689501.1
• Gene: ORAI3 / 93129
• HGNCID: 28185
• Length: 295
• Species: Homo sapiens
• Sequence 2: XP_012824392.1
• Gene: orai2 / 100380109
• XenbaseID: XB-GENE-5781666
• Length: 259
• Species: Xenopus tropicalis
• Alignment Length: 288
• Identity: 161/288 - (55%)
• Similarity: 196/288 - (68%)
• Gaps: 51/288 - (17%)

Human     6 GDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSAL 70
            |.|.:..|..|:.:..  ..:|.|::.|.|::||..::||::|||||:|||||||||||||||||
 Frog     6 GVAAKSRPCPPQLQEE--EVSYPEWISRSYVELMSLNEHSMQALSWRKLYLSRAKLKASSRTSAL 68

Human    71 LSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSV 135
            |||||||||||||||:||.||||||:||||||||||||||||||:|||:||:||||||:||||||
 Frog    69 LSGFAMVAMVEVQLEADHAYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSV 133

Human   136 HQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPV 200
            .:|||:|:||::||||.|||.:||.||||||||:.||||:|:.:|
 Frog   134 KESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSP-------------------- 178

Human   201 ATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALH 265
                    .|..:..|...|                    |..||:||||||||.||||:.||:|
 Frog   179 --------KLSSNDTSTVSS--------------------GQAAAIASTAIMVPFGLVFIVFAVH 215

Human   266 FYRSLVAHKTDRYKQELEELNRLQGELQ 293
            ||||||:|||||..|||.||..| .:||
 Frog   216 FYRSLVSHKTDRQFQELNELAEL-AQLQ 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORAI3	NP_689501.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/16 (25%)
		Orai-1	48..276	CDD:462291	138/227 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..238		3/33 (9%)
orai2	XP_012824392.1	Orai-1	46..226	CDD:462291	138/227 (61%)