DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNB2 and Shawl

DIOPT Version :9

Sequence 1:NP_004761.2 Gene:KCNB2 / 9312 HGNCID:6232 Length:911 Species:Homo sapiens
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:1037 Identity:265/1037 - (25%)
Similarity:390/1037 - (37%) Gaps:325/1037 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSIL 100
            |:.:||.|:.:|....||.::|.|||.:         |.|...:|:...||||||||||.||.||
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQIL 61

Human   101 NFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELRREAETMR 160
            |:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|...
  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT 126

Human   161 ERE-------GEEFDN---TCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTL 215
            |.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|.
  Fly   127 EEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191

Human   216 P-----------------------------ELQETDEFGQ------------------------- 226
            |                             |..:|.::.|                         
  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256

Human   227 ------------------------------LN---DNRQLAH---------------------VE 237
                                          ||   :.:.|.|                     ||
  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVE 321

Human   238 AVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQI 302
            .||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......:::.
  Fly   322 LVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLEA 378

Human   303 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDATKF 365
            |.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |....:|
  Fly   379 FSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQF 443

Human   366 TSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QKR 429
            .|||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.|
  Fly   444 KSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQAR 508

Human   430 QEKAIKRREAL----ERAKRN------------------------GSIVSMN------------- 453
            .:...|||..|    .|.||.                        |.:|.:.             
  Fly   509 SKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVGH 573

Human   454 -------LKDAFARSMELIDVAVEKAGESANTKDSADDN--HLSPSRWKWARKALSETSSNKSFE 509
                   .||||             .|....|.:....|  .|.|::......|::         
  Fly   574 SAAGAPMFKDAF-------------GGAKIGTVNVNGVNVIGLHPAQRTTTTMAMA--------- 616

Human   510 NKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEI 574
                             .:.:.|..:||...::...:.|.|..|||.:.........|::     
  Fly   617 -----------------MNEADPTPMSALTYQVPMLQPTPTPAHSHGHAHGHAHGLGPAS----- 659

Human   575 EMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPG 639
                                ..|.|::|:....:.|...|....:|..|...|...:..|. :..
  Fly   660 --------------------AAMTSSASLTGSAASAAVATAAAAAPAGPSFISSDYLSVPA-VQS 703

Human   640 TEEHQRARGPPFLTLSREK--GPAARDGTLEYAPVDITVNLDASGSQCGLHS------------- 689
            .:......|..|:...:.|  ||..|.   :..|:.:|.:..||.:...::|             
  Fly   704 LQPRAATTGHDFMLPLQPKLLGPLERK---DQHPLQLTAHNLASDTHQLMYSGHAHSQHKVGGGA 765

Human   690 ------PLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTT 748
                  |..|.:.|..|    .|...:..|:..::|:...|::.|. .:..:|:|.:.|      
  Fly   766 AVLNVPPTLSMSHTQMP----PGIASMGQRTPNLSFRPAHGASSQV-ATVQQPIPHSHA------ 819

Human   749 PQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRF--PKQKLFPFSSRERRSFTEIDTG- 810
             .|.||             ....::|....|.|.|....|  ||..|....|.:..|.|: |.| 
  Fly   820 -CHAST-------------NCNIKISVASAGLSVGCPDEFRTPKVTLLDDLSDDVNSSTD-DCGD 869

Human   811 ----DDEDFLE------LPGAREE-KQVDSSPNCFADKPSDGRDPLREEGS-VGSSSPQDTG 860
                ||.|..|      .|..:|. .:.....:...|  :||.|....||| ||..|....|
  Fly   870 CCLVDDSDTYEGTTINNGPSGQENGTEAIGLDDGLLD--NDGEDEEDGEGSGVGGDSGDSLG 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNB2NP_004761.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
BTB 37..143 CDD:197585 46/105 (44%)
BTB_2 37..136 CDD:280393 43/98 (44%)
Ion_trans 230..428 CDD:278921 93/221 (42%)
Ion_trans_2 341..422 CDD:285168 48/82 (59%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 4/4 (100%)
Kv2channel 471..759 CDD:281514 50/310 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 1/30 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..571 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..665 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..739 11/72 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..865 30/116 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 892..911
ShawlNP_001097131.2 BTB 7..99 CDD:197585 44/100 (44%)
BTB_2 7..97 CDD:280393 43/98 (44%)
Ion_trans 307..506 CDD:278921 91/206 (44%)
Ion_trans_2 <449..499 CDD:285168 32/49 (65%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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