DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASIC3 and ppk26

DIOPT Version :9

Sequence 1:	NP_064717.1	Gene:	ASIC3 / 9311	HGNCID:	101	Length:	549	Species:	Homo sapiens
Sequence 2:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	122/567 - (21%)
Similarity:	198/567 - (34%)	Gaps:	155/567 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVR 65
            :|..||.:.|:   :.|..:....::||:.::.......|.|..|.:.:||||.|.   |...:.
  Fly    58 IKYGSGFQAAK---AIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTC---VKLTLN 116

Human    66 YYREFHHQ---TALDERES--HRLIFPAVTLCNINPLRRS--RLTPN---------------DLH 108
            .:.::::.   .:..|:.:  .::.|||||:|.....||.  ..|.:               ||.
  Fly   117 IWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLS 181

Human   109 WAGSALLG-----LDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRG 168
            .....|.|     .:|..|...|          |.......::...........||..|:|::|.
  Fly   182 DKQKGLYGAVSQVCEPHLHDVTL----------GNKTRRGMEIIDALTEVSPHFDDTYLNCKWRN 236

Human   169 QP--CGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEET 231
            .|  |. :.|....|..|.|::||| ...||:.                 :.|..:|.:...||.
  Fly   237 SPVKCS-DIFHKFVTEDGVCFSFNS-LSPAEIF-----------------RAEGIIPDFIFREEN 282

Human   232 PFEVGIRVQ---IHSQEEPPIIDQ-LGLGVSPGYQTFVS---------CQQQQLSF---LPPPWG 280
            ...:...|:   ..|.:..|..:: ||.|...|...|:.         |:.....|   |..| |
  Fly   283 RLSMDWNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTP-G 346

Human   281 DCSSASLNPNYEPEP----------------SDPLGSPSPSPSP-------------PYTLMGCR 316
            |.  |.::..|...|                ||.|....|:...             .|:...|.
  Fly   347 DV--AQVSKQYFRIPFDQEVLISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCE 409

Human   317 LACETRYVARKCGCRMVYMPGDV--PVCSPQQYKNCAHPAIDAMLRKD----------------S 363
            |.|...:...||||....||.:|  |||.....| |.:.|.|.:|.::                .
  Fly   410 LECLANFTLTKCGCVKFSMPRNVNMPVCGDASLK-CYNQAEDELLLREFTQGLVNAGENTRGETE 473

Human   364 CACPNPCASTRYAKELSMVRIPSRAA------------ARFLARKLNRSEAYIAENVLALDIFFE 416
            |.|...|.|..|..|:|......:..            ::....|::|           :.|||:
  Fly   474 CNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR-----------VSIFFK 527

Human   417 ALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEV 463
            ...:.|..:.:.|..::.|.:.||.:|||:|.|:|:|:|:: |.|.|
  Fly   528 EAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVELI-YFCTV 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	117/548 (21%)
ASIC3	NP_064717.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..307		7/37 (19%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	114/543 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.970