DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF235 and salr

DIOPT Version :9

Sequence 1:NP_004225.3 Gene:ZNF235 / 9310 HGNCID:12866 Length:738 Species:Homo sapiens
Sequence 2:NP_001245983.1 Gene:salr / 34568 FlyBaseID:FBgn0000287 Length:1267 Species:Drosophila melanogaster


Alignment Length:1103 Identity:205/1103 - (18%)
Similarity:309/1103 - (28%) Gaps:494/1103 - (44%)


- Green bases have known domain annotations that are detailed below.


Human    59 QLERE---EKLWMKELQTQRGKHSGDRNQNE---MATLHKAGLRCF------SLGELSCWQIK-- 109
            |:|.|   |....:|...:||:.....|.||   ::.:...|....      ||..|...::.  
  Fly    62 QMEAEAVPESDTERETAEERGEEQEPENSNEALDLSLISSGGRESLPGSGHVSLEALQHTKVAVA 126

Human   110 ---------RHIASKLARSQDSMINIEGK---SSQFPKHHDSPCQVGAGESIQASVDDNCLVNHI 162
                     .|.::.||..|.::.|::.:   ..|..:|..|  |:...|:..           :
  Fly   127 QFAATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQS--QLKRAEAAA-----------L 178

Human   163 GDHSSIIENQEFP-----TGKVPNSWSKIYLN-----ETQNYQRSCKQTQMK------------- 204
            |.||...|.:|.|     ..|.|.:..|..|.     |::..|.|.::...|             
  Fly   179 GRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRKAEP 243

Human   205 ----NKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSDCGKDTLKVSPLTQRSIHTGQKTYQG 265
                :.:|      ||.|.::.....|  |......:..:|      :..|.:|:          
  Fly   244 EGYQSMMC------DISSSLASSIITN--HDPPPAPNEPNC------LEMLQRRT---------- 284

Human   266 NECEEAFNDSSSLELHKQVHLGKKSPACSTHEKDTSYSSGIPVQQSVRTGK-KRYWCHECGKGFS 329
               ||.. ||:|..||          |....|:.:.|:|    :::...|: .::.|..|||.|.
  Fly   285 ---EEVL-DSASQSLH----------AAQMQEEYSEYAS----KEAQSRGEIFKHRCKYCGKIFG 331

Human   330 QSSNLQTHQRVHTGEKPYTCHECGKSFNQSSHLYAHLPIHT----------GEKPYRCDSCGKGF 384
            ..|.||.|.|.||||:|:.|:.||..|....:|..|...||          |..| .....|:|.
  Fly   332 SYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP-NVGHSGQGQ 395

Human   385 SRSTDLNIHCRVHTGEKPYKCEVCGKGFTQ--------------------------------RSH 417
            .:.....|..       |:...|...|..|                                :||
  Fly   396 VQGEQYPIRL-------PFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSH 453

Human   418 LQAHERIHT------------GEKPYK------------CGDCGKRFSCS-------------SN 445
            ... ||:.|            .|||.|            .|...||.:.:             .:
  Fly   454 SPV-ERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEH 517

Human   446 LHTHQRVH-----TEEKPY----------------------KCDECGKCFSLSFNLHSHQRVHTG 483
            ||..:.|.     .|.:|.                      |..|..|...|..|:.:..     
  Fly   518 LHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKL----- 577

Human   484 EKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQAHQRVHTGEKP----YK 544
            ..|.:|..|.|..|..||.|.|.|.||||:||||.:||:.|:.....:||..:|..:.|    :|
  Fly   578 TDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFK 642

Human   545 CEVCGKRFNWSLNLHNHQRVHT-----------GEKPYKCEECG---------KGFSQASNLQAH 589
            |.||.::|:..:.|..|.|:||           ...|.:.|..|         .|.|...:....
  Fly   643 CPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTT 707

Human   590 QSVHTGEK--------------------------------------------------------- 597
            .|.|:|::                                                         
  Fly   708 ISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDER 772

Human   598 ----------------------------------------------------------------- 597
                                                                             
  Fly   773 SHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLM 837

Human   598 ---------------------------------PFKCDACQKRFSQASHLQAH-QRVH-----TG 623
                                             |..|:.|.|.....:.|::| |..|     ||
  Fly   838 AAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATG 902

Human   624 --EKPYKCDTCGKAFSQRSNLQVHQII---------HTGEK-------PFKC------------- 657
              ::| :|...|..:..:..|..:...         .:|||       ||..             
  Fly   903 HAQRP-QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPD 966

Human   658 -EECGKEFSWSAG--------------------------LSAH----------QRVHTGEKP--- 682
             |:...|...|||                          |.||          |.:.:...|   
  Fly   967 QEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSS 1031

Human   683 --------YTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGN 737
                    :.|..|.:.||.:|....|.|.|||::|:.|:||.|.|:.:.:|..|...|...|
  Fly  1032 LDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTN 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF235NP_004225.3 KRAB A domain 6..47
KRAB 8..68 CDD:214630 4/11 (36%)
KRAB 8..47 CDD:279668
KRAB B domain 48..80 7/23 (30%)
C2H2 Zn finger 266..285 CDD:275368 7/18 (39%)
COG5048 321..662 CDD:227381 117/663 (18%)
C2H2 Zn finger 321..341 CDD:275368 10/19 (53%)
zinc finger domain 321..341 10/19 (53%)
zf-H2C2_2 333..358 CDD:290200 13/24 (54%)
C2H2 Zn finger 349..369 CDD:275368 6/19 (32%)
zinc finger domain 349..369 6/19 (32%)
C2H2 Zn finger 377..397 CDD:275368 3/19 (16%)
zinc finger domain 377..397 3/19 (16%)
zf-H2C2_2 389..414 CDD:290200 4/24 (17%)
C2H2 Zn finger 405..425 CDD:275368 7/51 (14%)
zinc finger domain 405..425 7/51 (14%)
zf-H2C2_2 417..442 CDD:290200 11/48 (23%)
C2H2 Zn finger 433..453 CDD:275368 5/32 (16%)
zinc finger domain 433..453 5/32 (16%)
zf-H2C2_2 448..469 CDD:290200 6/47 (13%)
C2H2 Zn finger 461..481 CDD:275368 4/19 (21%)
zinc finger domain 461..481 4/19 (21%)
zf-H2C2_2 476..498 CDD:290200 4/21 (19%)
C2H2 Zn finger 489..509 CDD:275368 9/19 (47%)
zinc finger domain 489..509 9/19 (47%)
zf-H2C2_2 501..526 CDD:290200 15/24 (63%)
C2H2 Zn finger 517..537 CDD:275368 6/19 (32%)
zinc finger domain 517..537 6/19 (32%)
zf-H2C2_2 529..553 CDD:290200 8/27 (30%)
C2H2 Zn finger 545..565 CDD:275368 7/19 (37%)
zinc finger domain 545..565 7/19 (37%)
zf-H2C2_2 560..582 CDD:290200 8/41 (20%)
C2H2 Zn finger 573..593 CDD:275368 5/28 (18%)
zinc finger domain 573..593 5/28 (18%)
zf-H2C2_2 585..610 CDD:290200 7/179 (4%)
C2H2 Zn finger 601..621 CDD:275368 6/20 (30%)
zinc finger domain 601..621 6/20 (30%)
zf-H2C2_2 613..638 CDD:290200 9/32 (28%)
C2H2 Zn finger 629..649 CDD:275368 3/28 (11%)
zinc finger domain 629..649 3/28 (11%)
zf-H2C2_2 641..665 CDD:290200 8/53 (15%)
C2H2 Zn finger 657..677 CDD:275368 9/69 (13%)
zinc finger domain 657..677 9/69 (13%)
zf-H2C2_2 670..694 CDD:290200 8/44 (18%)
C2H2 Zn finger 685..705 CDD:275368 7/19 (37%)
zinc finger domain 685..705 7/19 (37%)
C2H2 Zn finger 713..733 CDD:275368 7/19 (37%)
zinc finger domain 713..733 7/19 (37%)
salrNP_001245983.1 zf-C2H2 321..343 CDD:278523 10/21 (48%)
C2H2 Zn finger 323..343 CDD:275368 10/19 (53%)
zf-H2C2_2 335..360 CDD:290200 13/24 (54%)
C2H2 Zn finger 351..371 CDD:275368 6/19 (32%)
C2H2 Zn finger 583..603 CDD:275368 9/19 (47%)
zf-H2C2_2 595..620 CDD:290200 15/24 (63%)
C2H2 Zn finger 611..631 CDD:275368 6/19 (32%)
C2H2 Zn finger 643..663 CDD:275368 7/19 (37%)
lambda-1 1013..>1061 CDD:212564 8/47 (17%)
zf-C2H2 1040..1062 CDD:278523 7/21 (33%)
C2H2 Zn finger 1042..1062 CDD:275368 7/19 (37%)
zf-H2C2_2 1054..1079 CDD:290200 11/24 (46%)
C2H2 Zn finger 1070..1090 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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