DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF235 and tmem208

DIOPT Version :9

Sequence 1:	NP_004225.3	Gene:	ZNF235 / 9310	HGNCID:	12866	Length:	738	Species:	Homo sapiens
Sequence 2:	NP_001120211.1	Gene:	tmem208 / 100145260	XenbaseID:	XB-GENE-941117	Length:	174	Species:	Xenopus tropicalis

Alignment Length:	51	Identity:	12/51 - (23%)
Similarity:	21/51 - (41%)	Gaps:	22/51 - (43%)

- Green bases have known domain annotations that are detailed below.

Human   159 VNHIG-----DHSSIIENQEFPTGKVPNSWSKIYLNETQNYQRSCKQTQMK 204
            :|.:|     |:||.:..::               ||.:  ||..::.|||
Frog   139 INVLGPWFTADNSSTVPQEQ---------------NEKR--QRRQERRQMK 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF235	NP_004225.3	KRAB A domain	6..47
		KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		KRAB B domain	48..80
		C2H2 Zn finger	266..285	CDD:275368
		COG5048	321..662	CDD:227381
		C2H2 Zn finger	321..341	CDD:275368
		zinc finger domain	321..341
		zf-H2C2_2	333..358	CDD:290200
		C2H2 Zn finger	349..369	CDD:275368
		zinc finger domain	349..369
		C2H2 Zn finger	377..397	CDD:275368
		zinc finger domain	377..397
		zf-H2C2_2	389..414	CDD:290200
		C2H2 Zn finger	405..425	CDD:275368
		zinc finger domain	405..425
		zf-H2C2_2	417..442	CDD:290200
		C2H2 Zn finger	433..453	CDD:275368
		zinc finger domain	433..453
		zf-H2C2_2	448..469	CDD:290200
		C2H2 Zn finger	461..481	CDD:275368
		zinc finger domain	461..481
		zf-H2C2_2	476..498	CDD:290200
		C2H2 Zn finger	489..509	CDD:275368
		zinc finger domain	489..509
		zf-H2C2_2	501..526	CDD:290200
		C2H2 Zn finger	517..537	CDD:275368
		zinc finger domain	517..537
		zf-H2C2_2	529..553	CDD:290200
		C2H2 Zn finger	545..565	CDD:275368
		zinc finger domain	545..565
		zf-H2C2_2	560..582	CDD:290200
		C2H2 Zn finger	573..593	CDD:275368
		zinc finger domain	573..593
		zf-H2C2_2	585..610	CDD:290200
		C2H2 Zn finger	601..621	CDD:275368
		zinc finger domain	601..621
		zf-H2C2_2	613..638	CDD:290200
		C2H2 Zn finger	629..649	CDD:275368
		zinc finger domain	629..649
		zf-H2C2_2	641..665	CDD:290200
		C2H2 Zn finger	657..677	CDD:275368
		zinc finger domain	657..677
		zf-H2C2_2	670..694	CDD:290200
		C2H2 Zn finger	685..705	CDD:275368
		zinc finger domain	685..705
		C2H2 Zn finger	713..733	CDD:275368
		zinc finger domain	713..733
tmem208	NP_001120211.1	DUF788	14..159	CDD:283310	5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910