Protein Alignment SOCS6 and Socs36E

DIOPT Version :10

• Sequence 1: NP_004223.2
• Gene: SOCS6 / 9306
• HGNCID: 16833
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 122/511 - (23%)
• Similarity: 198/511 - (38%)
• Gaps: 111/511 - (21%)

Human    52 ASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDV 116
            |:|.:..:|:         :.|..:|.||..:...|:............:......:..:.:.:|
  Fly   186 ANCPLEADDD---------DDLDESLLRRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEV 241

Human   117 RAQRPIRS-TSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQS 180
            ....|:.: .|..:.|.|.   |:..:|:..:|.:.. ..|||...::.|.|............|
  Fly   242 LESLPVSNMLSAGTQHSSK---PVSRSNNSNSCCRSR-SSKALSMGAATSSASGSASTSVSTSTS 302

Human   181 ------ETTCQEQANSLK-------SSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMY 232
                  :..|::....|:       ||.|:..|        ...|:.::|:
  Fly   303 SKRRCCKCKCRDAIRGLRDMLPSSSSSVSNKKD--------AAAVVAMVPR-------------- 345

Human   233 PLEGSRSYCLDSSSPMEVSAVPPQVG---GRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTT- 293
                 :|...|..|      .||.:|   |.:....:||..::.|..|:  .....:.|:|..|
  Fly   346 -----KSRTADRRS------TPPTLGTSSGGSQRRMQSQRIRNSVAVPD--ASHHHHQLIIRITS 397

Human   294 -GVMLQSPRAGHDDV----PPLSPLLPPMQN---NQIQRNFSGLTGTEAHVAESMRCHLNFDPNS 350
             |.:::||..|...|    .|.||..||...   .......:|..|..|  |.:|..|...|
  Fly   398 PGFVVESPNGGRVTVVTEPAPQSPQTPPRPRPLATVAPAGGAGHAGIGA--ARNMTVHSQID--- 457

Human   351 APGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDR 415
                             .:..|..:|:|:....:|||.:.|:|||..|...|:|:||:|||:.:.
  Fly   458 -----------------FMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEE 505

Human   416 YLLSLSFRSHGKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPG 479
            :|.|::||.:|::||.|||.|..:||| ...|.|....::..|:|| .:|.....|
  Fly   506 FLFSVTFRKYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEH-YKDPACVMF--------- 560

Human   480 SATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
               :...||.|:.| .|..|||.|.|..|...|..|.|.::.||.::|.||:|.||
  Fly   561 ---FEPCLTIPLHR-RQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHY 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS6	NP_004223.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..105		2/24 (8%)
		SH2_SOCS6	373..472	CDD:198250	38/99 (38%)
		SOCS_SOCS6	495..535	CDD:239709	16/39 (41%)
Socs36E	NP_523593.5	SH2	463..563	CDD:472789	38/112 (34%)
		SOCS	575..626	CDD:470605	17/38 (45%)