Protein Alignment SOCS6 and Socs16D

DIOPT Version :10

• Sequence 1: NP_004223.2
• Gene: SOCS6 / 9306
• HGNCID: 16833
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_001259662.1
• Gene: Socs16D / 32760
• FlyBaseID: FBgn0030869
• Length: 1021
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 146/583 - (25%)
• Similarity: 207/583 - (35%)
• Gaps: 191/583 - (32%)

Human    44 GSCYGKDMASCDINGEDEKGGKNR----------SKSESLMGTLKRRLSAKQKSKGKAGTPSG-- 96
            ||..|....:.|.:||..|.||.|          |:||.|..||.............||.|:.
  Fly   517 GSGTGAGTETSDGDGEKSKHGKYRTPVGVGMGQVSESEPLHMTLDEVKQFYHTLYSDAGKPTPKP 581

Human    97 --SSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALV 159
              .|::|..:|.|                                  ||:..|..:....|....
  Fly   582 MVKSSNETIWSVS----------------------------------TNTTTTTARTRSSVGTTR 612

Human   160 HSSSPSPALNGV-----------------------RKDFHDLQSETTCQEQANS----------L 191
            ....|..|.||.                       :::.|:|.::.......|:          .
  Fly   613 GGGGPPGAGNGAGGASSDGGVGGGSAGGGGGKYLSKQNKHNLDNDKLNNNNNNNNNHQPSQQQLE 677

Human   192 KSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPL----EGSRSYCLDSSS------ 246
            |....|:.......::||     |..:...|:|:.|.:....:    ..:.|.|..|.:
  Fly   678 KPPTEHHNQHQPPNNKHV-----LHSEKKSQFTLNLKQRFCSIFRFRRSNHSRCRGSGNNQTGTF 737

Human   247 ---------------PMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVM 296
                           |:.|....|...|      ::|:..:|            ||.||
  Fly   738 ASANANAAATAPLIPPIAVITSAPGAAG------QTQLASEL------------NGTLI------ 778

Human   297 LQSPRAGHDDVPPL-------SPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSA-PG 353
                 ....|.|..       |..|||:                              |..| |.
  Fly   779 -----TAEADEPNADLRKKFQSRALPPL------------------------------PKKALPF 808

Human   354 VARVY--DSVQSSGPMVVTS---------LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFL 407
            .|..|  ::|:|....|.|:         .|..::|:...||||||::...||..|::.|||||:
  Fly   809 TAAAYAIEAVKSEPEEVKTNAIQEPRALQFTSSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSFI 873

Human   408 VRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCY 472
            |||||||.|:.||||:.:....|.|||...|.|||......:..| |.:.||.::..|.:|.:.:
  Fly   874 VRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSYAKFKSQT-ITEFIEKAVEHSRSGRYLF 937

Human   473 SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVI-RQYTRIDLIQKLPLPNKMKDYLQEKH 534
            ...|.|......|:||||||||..|:|||::||||| :...|.||||.||||.::.|||..||
  Fly   938 FLHRRPEHGPMRVQLTNPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYLNYKH 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOCS6	NP_004223.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..105		5/28 (18%)
		SH2_SOCS6	373..472	CDD:198250	42/98 (43%)
		SOCS_SOCS6	495..535	CDD:239709	23/41 (56%)
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	42/98 (43%)
		SOCS_SOCS7	960..1009	CDD:239710	23/41 (56%)