Protein Alignment ACVR2B and acvr2b

DIOPT Version :9

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001006871.1
• Gene: acvr2b / 448641
• XenbaseID: XB-GENE-484248
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 496
• Identity: 425/496 - (85%)
• Similarity: 468/496 - (94%)
• Gaps: 5/496 - (1%)

Human    39 GSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDF 103
            |||..|.|||||||||||||||:|||||:|.||||:||||||||||||:||.|||||||||||||
 Frog    19 GSGHDEVETRECIYYNANWELEKTNQSGVESCEGEKDKRLHCYASWRNNSGFIELVKKGCWLDDF 83

Human   104 NCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAP-TLLTVLAYSLLPI 167
            ||||||||:|.||||||:|||||||:||::||||||.    .|::|.|..| ::|.:|.||||||
 Frog    84 NCYDRQECIAKEENPQVFFCCCEGNYCNKKFTHLPEV----ETFDPKPQPPASVLNILIYSLLPI 144

Human   168 GGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMN 232
            .|||:.:|||||||||||||||||||:||||||||||:|||||||||||||||||||||||:|:|
 Frog   145 AGLSMAILLAFWMYRHRKPPYGHVDINEDPGPPPPSPMVGLKPLQLLEIKARGRFGCVWKARLLN 209

Human   233 DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDY 297
            ::|||||||:|||||||.|:|||:|.||||||||:||||||||||||:|||||||||||||||||
 Frog   210 EYVAVKIFPIQDKQSWQCEKEIFNTVGMKHENLLEFIAAEKRGSNLEMELWLITAFHDKGSLTDY 274

Human   298 LKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFG 362
            ||||::|||||||:.|||:|||:|||||||.|:||||||:|||||||||||||::||||:|||||
 Frog   275 LKGNLVTWNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADFG 339

Human   363 LAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP 427
            ||||||||||||||||||||||||||||||||||||||:|||||||||||||||:||||.|||||
 Frog   340 LAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAMGLVLWEIVSRCTAADGP 404

Human   428 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 492
            |||||||||||||||||||:||||||||||||..|||||||||||||||||||||||||||||||
 Frog   405 VDEYMLPFEEEIGQHPSLEDLQEVVVHKKMRPVFKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 469

Human   493 GCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 533
            ||||||:|.||:||||||||||||:||||||||||||||||
 Frog   470 GCVEERISQIRKSVNGTTSDCLVSIVTSVTNVDLPPKESSI 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	Activin_recp	48..138	CDD:279413	77/89 (87%)
		STKc_ACVR2b	215..505	CDD:271042	258/289 (89%)
		S_TKc	219..492	CDD:214567	243/272 (89%)
acvr2b	NP_001006871.1	Activin_recp	42..114	CDD:366445	61/71 (86%)
		STKc_ACVR2b	192..482	CDD:271042	258/289 (89%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	531	1.000	Domainoid score	I3231
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H863
Inparanoid	1	1.050	921	1.000	Inparanoid score	I3563
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D104990at32523
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		oto158603
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080