Protein Alignment ACVR2B and wit

DIOPT Version :10

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 169/557 - (30%)
• Similarity: 269/557 - (48%)
• Gaps: 105/557 - (18%)

Human    27 GDTRAGGQ---------PLPKGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYA 82
            ||..:.|:         |:|     .|...|.|                       .|....|:.
  Fly    42 GDQDSSGELQEQQVESTPIP-----SEPHRRTC-----------------------PDGYTFCFT 78

Human    83 SWRNSSGTIELVKKGCWLDDFN----CYDRQECVA---TEENPQVYFCCCEGNFCNERFTHLPEA 140
            .|..::....:||:|||.|:.:    | .:.||.:   |.:...:|:|||.|..||.:::
  Fly    79 IWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS----- 137

Human   141 GGPEVTYEPPP----------------TAPTLLTVLAYSLLPI-GGLSLIVLLAFWMYRHRKPPY 188
                 ..||.|                |.....:.||.::|.: |||:.:.:..|...::.:...
  Fly   138 -----VVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAK 197

Human   189 GHVDIHEDP----GPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQ 249
            ...:..|.|    ||...|.|..:..:.|:.:...|::|.|.|..|.:..|||||:|.:..|.:.
  Fly   198 EKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYV 262

Human   250 SEREIFSTPGMKHENLLQFIAAEKRGS-NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAE 313
            :||.|::.|.|:...||.:...::|.: :..:|..|:.:....|.|.|:|..|.:|::|.|.:..
  Fly   263 NERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLR 327

Human   314 TMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF---------EP 369
            :::||:|:||.::.  .|:.|||.:||||..::|||:::||:..:||||.|::.         |.
  Fly   328 SITRGISHLHTELR--LGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEV 390

Human   370 GKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRIDMYAMGLVLWELVSRCKAADGP---V 428
            ......:..:|||.||||||:||||:|. ||   :..::|:||:||||||:.:||.....|   .
  Fly   391 AMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQAT 454

Human   429 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCV--TIEECWDHDAEARLS 491
            ..|..|:|:|:|.|||.:::|.:||..|.||.....|  ..|.|...|  |.|:||||||:|||:
  Fly   455 PPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW--GGGAAAKVVRDTCEDCWDHDADARLT 517

Human   492 AGCVEER---VSLIRRSVNGTTSDCLV---SLVTSVT 522
            :.|.|||   :|.:|.......|..|:   :||.|.|
  Fly   518 SLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	22/96 (23%)
		STKc_ACVR2b	215..505	CDD:271042	117/310 (38%)
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	28/134 (21%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	115/304 (38%)