Protein Alignment ACVR2B and babo

DIOPT Version :10

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_476999.1
• Gene: babo / 35900
• FlyBaseID: FBgn0011300
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 169/554 - (30%)
• Similarity: 264/554 - (47%)
• Gaps: 108/554 - (19%)

Human    24 PQAGDTRAGGQPLPKGSGRGEAETRECIYYNANWELER----------TNQSGLERCEGEQDKRL 78
            ||.||  |.|...|       |.|.:...|.|....::          |.:.....||.:.
  Fly    94 PQDGD--ASGAVAP-------AVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDG---- 145

Human    79 HCYAS-WRNSSGTI----------ELVKKG--CWLDDFNCYDRQECVATEENPQ--------VYF 122
            .|:.| .:||.|:|          ::...|  .|.:|          .....|.        .:.
  Fly   146 FCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCND----------GLHGGPTARPVGRNGAHA 200

Human   123 CCCEGNFCN---------ERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVL--L 176
            ||.:.:|||         :|...:.|  |.:::.:  ...|..||...:..:.:|....|..  .
  Fly   201 CCKDRDFCNRFLWPKTKDQRSDRVEE--GRQISVQ--DYVPHRLTSWEFVAIILGATLFICFTGT 261

Human   177 AFWMY--RHRKPPYGHVDIHEDPGPPP-----------------PSPLVGL---------KPLQL 213
            :.|.|  |.::...|.....||....|                 .|...||         :.:||
  Fly   262 STWYYCQRRKRMASGRTFAKEDSAYDPILNGNTTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQL 326

Human   214 LEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNL 278
            ..:..:||||.||:.:...:.||||||..:::.||..|.||:.|..::|||:|.||||:.:.:..
  Fly   327 CHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGT 391

Human   279 EVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDF 343
            ..:|||:|.:|:.|||.|||..:.:..|.:.:::.:::.||::||.|:...||   ||:|||||.
  Fly   392 WTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRG---KPAIAHRDL 453

Human   344 KSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD---THGQVGTRRYMAPEVLEGAINFQR-DAFLR 404
            ||||:|:||:|:..:.|.|||||........|   || :|||:||||||||:.::|.|. |::.|
  Fly   454 KSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTH-RVGTKRYMAPEVLDESMNDQHFDSYKR 517

Human   405 IDMYAMGLVLWELVSRCKAADGPV-DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH 468
            .|:||.||:|||:..||..  |.: |||.||:.:.:...||:||:::||..:|.||.|.:.|...
  Fly   518 ADVYAFGLILWEIARRCNM--GMIYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHAS 580

Human   469 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLI 502
            ..|..:...::|||..:..|||:|..:::.::.|
  Fly   581 DVLHNMAKVMKECWYPNPVARLTALRIKKTLASI 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	22/129 (17%)
		STKc_ACVR2b	215..505	CDD:271042	120/293 (41%)
babo	NP_476999.1	TFP_LU_ECD_Babo	127..210	CDD:467127	17/96 (18%)
		GS	294..324	CDD:197743	3/29 (10%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	120/293 (41%)