Protein Alignment ACVR2B and sax

DIOPT Version :10

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 145/496 - (29%)
• Similarity: 242/496 - (48%)
• Gaps: 89/496 - (17%)

Human    57 WELERTNQSGLERCEGEQDKRLHCYAS-WRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQ- 119
            :|...|.|:.::           |:.| .|::.|.:: ..:||....    |:...:.::.:.:
  Fly    90 YEFTHTCQNAIQ-----------CWKSRTRDADGQVQ-ESRGCSTSP----DQLPMICSQNSLKI 138

Human   120 -----------VYFCCCEGNFCNE-RFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSL 172
                       |...||.|::||| .|..|......:||.....|:.....::|.    :|...:
  Fly   139 NGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAV----LGPFLV 199

Human   173 IVLLA----FWMYRHRKPPYGHVDIHEDP------------------------------GPPPPS 203
            |.||.    |::.|..:.........:||                              |.....
  Fly   200 IALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGL 264

Human   204 PLVG----LKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHEN 264
            ||:.    .|.:.|:|...||::|.||:.....:.:|||||..:|::||:.|.||:||..::|||
  Fly   265 PLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHEN 329

Human   265 LLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWC 329
            :|.||.::....|...:|||:|.::..|||.|:|..|.::.|::..:..:::.||.:||.::
  Fly   330 ILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI--- 391

Human   330 RGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAV-------RFEPGKPPGDTHGQVGTRRYMA 387
            .|:..||::||||.||||:|:.|:.:.|:|||||||       :.:.|..|     :|||:||||
  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMA 451

Human   388 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 451
            ||||:.:|:.: .:|..|.|:||.|||||| |.|...:.|..:||.:||.:.:...||.|::::|
  Fly   452 PEVLDESIDLECFEALRRTDIYAFGLVLWE-VCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKV 515

Human   452 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 492
            |.....||:|.:.|.....:..:...::|||..:.:.||.|
  Fly   516 VCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	18/93 (19%)
		STKc_ACVR2b	215..505	CDD:271042	109/286 (38%)
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	17/91 (19%)
		TM_EGFR-like	182..218	CDD:213052	8/39 (21%)
		TGF_beta_GS	247..274	CDD:462503	3/26 (12%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	111/296 (38%)