Protein Alignment ACVR2B and tkv

DIOPT Version :10

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 167/564 - (29%)
• Similarity: 262/564 - (46%)
• Gaps: 119/564 - (21%)

Human    39 GSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASW----RNSSGTIELVKKG-C 98
            |||.|...     |.:|:.|..:|         .|..:.|.||...    ..|:||.|....| |
  Fly    56 GSGPGSEG-----YEDADNEKSKT---------VENARSLTCYCDGSCPDNVSNGTCETRPGGSC 106

Human    99 WLDDFNCYDRQE----------CVATEEN-----------PQVY----FCCCEGNFCNERFTHLP 138
            :......||...          |:..|:|           |.::    .||.:.:|||.   .|.
  Fly   107 FSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNR---DLY 168

Human   139 EAGGPEVTYEPPPTAPT------LLTVLAYSLLPIGGLSLIVLLAFWMYRHRK------------ 185
            ....|::| .|.|..|.      .|.|....::.:....|||....:.|:.|:
  Fly   169 PTYTPKLT-TPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINSM 232

Human   186 -----PPYGHVDIHEDPGPPPPSPLVG----LKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFP 241
                 .|...: :.:..|.....||:.    .|.:|::.:..:||:|.||.|:..::.||||.|.
  Fly   233 CNSQLSPLSQL-VEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFF 296

Human   242 LQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWN 306
            ..::.||..|.||:.|..|:|:|:|.||||:.:|:....::.|||.:|:.|||.|||..::|...
  Fly   297 TTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQ 361

Human   307 ELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEP-- 369
            :|..:|.:::.||::||:::   .|...||:|||||.||||:|:|.:....:|||||||::..
  Fly   362 KLQLLAFSLASGLAHLHDEI---FGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSEL 423

Human   370 -----GKPPGDTHGQVGTRRYMAPEVLEGAIN-FQRDAFLRIDMYAMGLVLWELVSRCKAADGPV 428
                 .:.|     :||||||||||||...:: .|.:.|.|.|||::||||||:..||..   ||
  Fly   424 DVIHIAQNP-----RVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYT---PV 480

Human   429 --------DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHD 485
                    ::|.||:.:.:...|:.|::..||..|..||.|...|.:...||.:...::|||..:
  Fly   481 SGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPN 545

Human   486 AEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPK 529
            ...||:|       ..:::::....:|||         :|:|.|
  Fly   546 PTVRLTA-------LRVKKTLGRLETDCL---------IDVPIK 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	25/119 (21%)
		STKc_ACVR2b	215..505	CDD:271042	113/305 (37%)
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	21/90 (23%)
		GS	238..266	CDD:197743	5/28 (18%)
		STKc_BMPR1	270..562	CDD:271046	113/309 (37%)