Protein Alignment ACVR2B and daf-4

DIOPT Version :9

• Sequence 1: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_498211.1
• Gene: daf-4 / 175781
• WormBaseID: WBGene00000900
• Length: 744
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 168/525 - (32%)
• Similarity: 251/525 - (47%)
• Gaps: 90/525 - (17%)

Human    49 ECIYYNANWELERTNQSGLER--CEGEQD-KRLHCYASWR------NSSGTIELVKK------GC 98
            ||:||: ..|.|::....:.:  |..|.. |.:.|.|.:.      ||:.....|.|      ||
 Worm    89 ECVYYD-EMECEKSGDCEITKKTCYSEAHLKAVGCLAVFGLPTQEINSTEPYLKVDKPQYKSLGC 152

Human    99 W----LDDFNCYDRQEC-VATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTA----- 153
            .    .|..||.:...| ........:..|||..|.||  ...|.|...|.:..:...:|
 Worm   153 MPYQHADSMNCENESSCRQGRSFRGGIGMCCCSTNNCN--MPDLIEMVNPSLKKDSDNSALLWAS 215

Human   154 -PTLLTVLAYSLLP-----IGGLSLIVLLAF-------WMYRHRKP------------------- 186
             |:.:.:.:....|     |..||:|:.:|.       |.::..|.
 Worm   216 TPSNMDLESLDKFPFYWIIIIALSVILCIALLILAYVGWKFQQNKKEEIKKQQKIKFDMEKTDAL 280

Human   187 PYGHVDIHEDPGPPPPSPLVGL------KPLQLLEIKARGRFGCVWKAQLMND-----FVAVKIF 240
            ..|:|.:.|     |...::.:      .|:...::.::||||.|:|||...|     .||||..
 Worm   281 EAGNVPLVE-----PEEEMIEMVETPKELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKL 340

Human   241 PLQDKQSWQSEREIFST----PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN 301
            ....|.|:.:|:.||..    |.. ::::::|:.|||.|.    |.|::|.||::.||.:.||.|
 Worm   341 NEFQKASFLAEKRIFDELNEYPKW-YKSIVEFVCAEKIGD----EYWIVTEFHERLSLYELLKNN 400

Human   302 IITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVR 366
            :|:......:..:|..||.:||:|.|:..|...|| |.|||.||||:|:|||:|..:||||||..
 Worm   401 VISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKP-IIHRDIKSKNILVKSDMTTCIADFGLARI 464

Human   367 FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCK--AADGPVD 429
            :.......|..|||||:|||:||:||||..|...||..:|:|:||||:||::||.|  ..|.| .
 Worm   465 YSYDIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEP-P 528

Human   430 EYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGC 494
            .|.:|| :.||..|::..::..||.||.||..:|..:||..::.|....||.||.:|.||::|||
 Worm   529 NYQMPF-QVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGC 592

Human   495 VEERV 499
            ...||
 Worm   593 AFARV 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2B	XP_005265640.1	Activin_recp	48..138	CDD:279413	27/108 (25%)
		STKc_ACVR2b	215..505	CDD:271042	123/296 (42%)
		S_TKc	219..492	CDD:214567	118/283 (42%)
daf-4	NP_498211.1	ET	<146..192	CDD:279950	12/47 (26%)
		PKc_like	310..603	CDD:304357	123/296 (42%)
		S_TKc	310..590	CDD:214567	118/287 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I2076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I2741
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		oto23557
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5044
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.000