Protein Alignment SRSF11 and Srp54

DIOPT Version :10

• Sequence 1: NP_001381331.1
• Gene: SRSF11 / 9295
• HGNCID: 10782
• Length: 494
• Species: Homo sapiens
• Sequence 2: NP_477347.1
• Gene: Srp54 / 34312
• FlyBaseID: FBgn0024285
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 181/568 - (31%)
• Similarity: 251/568 - (44%)
• Gaps: 160/568 - (28%)

Human    28 GGGGTEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPEKLESSKNLLLCDSPLPVSSRVCFV 92
            ||....||||||::|.|:.:||:||||.:|||:|:||:|          .:.|...||.||:|:|
  Fly     3 GGNTPRVIQVTNIAPQATKDQMQTLFGNIGKIEEIRLYP----------TIRDVSCPVQSRICYV 57

Human    93 KFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNP 157
            |:.|..|..||||||||||:||||||:|..  .||:|.:||.:|.....|.||......|| |..
  Fly    58 KYTDTTSVPVAQHLTNTVFIDRALIVIPVL--AIPEEYRALEMLKNGTIVPGLQKPDSKLP-PEV 119

Human   158 LTQI-GAVPLAALGAPTLDPALAALGLPGANLNSQSLAADQLLKLMSTV---------------- 205
            :.:| |.:|...:  .|.||.|....||..........|.::.::..|:
  Fly   120 INRIEGQLPQQVI--KTYDPKLVEFNLPEYPALPSFYDARKIEEIRRTIIVCDVKNEWRLDDLME 182

Human   206 ----------------DPK------------------------------LNHVAAGLVSPSLKSD 224
                            |.|                              :.|....:..|..||:
  Fly   183 CFQRAGEVKYARWAEKDNKTYCMIEFCEQTSIIHALRMQGQEFKGGHLSVYHSTYSITKPEAKSN 247

Human   225 TSSK-EIEEAMKRVREAQSLISAAIEP---DKKEEKRRHSRSRSRSRRRRTP------------- 272
            .::: ||||||..|:||||:|||||:|   ...::|||.||||||||.|||.
  Fly   248 EAAQAEIEEAMTIVKEAQSMISAAIDPVIGMLAKDKRRRSRSRSRSRDRRTSRSRSHRSTSRRRS 312

Human   273 --SSSRHRRSRSRSRR-RSHSKSRSRRRSKSPRRRRSHSRERGRRSRS-------TSKTRDKKKE 327
              |.||.|||.||||| ||..|..||.|||..|.|...|..|.|||||       :|::|.|:..
  Fly   313 RRSGSRERRSVSRSRRSRSRGKHSSRSRSKRSRSRHRRSSSRSRRSRSRGGKHSRSSRSRGKRSR 377

Human   328 DKEKK---RSKTPPKSYST-----ARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRR 384
            .:.::   ||:: .:|:.|     ....||.||||.::..||...|.:.|||..::.|.||.|..
  Fly   378 SRHRRSTSRSRS-SRSHGTGGGGSGNGKRSRSRERSKKSHRSEKHSSRSPRSRSKRSSPSPPPAT 441

Human   385 HKKEKKKDKDKERSRDE---RERSTSKKKKSKDKEKDRERKSESDKDVKVTRDYDEEEQGYDSEK 446
            ..|.:     ..||:|.   ..:|:.::.:|:..|..:.:....|.:||.:|.
  Fly   442 GSKSR-----SSRSKDPVIVSAKSSRRRDRSRTPETRKLKSISEDTEVKSSRS------------ 489

Human   447 EKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD 494
                     ...|...|..||||                 .::||:|:
  Fly   490 ---------SADSKSRKSVSVEK-----------------SDNMDISN 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF11	NP_001381331.1	RRM_SRSF11	34..124	CDD:409940	48/89 (54%)
Srp54	NP_477347.1	RRM_SRSF11_SREK1	9..85	CDD:409704	47/85 (55%)
		RRM2_SREK1	160..242	CDD:409705	4/81 (5%)