Protein Alignment MARS2 and MSM1

DIOPT Version :10

• Sequence 1: NP_612404.1
• Gene: MARS2 / 92935
• HGNCID: 25133
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_011687.1
• Gene: MSM1 / 853081
• SGDID: S000003403
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 590
• Identity: 212/590 - (35%)
• Similarity: 291/590 - (49%)
• Gaps: 82/590 - (13%)

Human    45 AYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGL- 108
            ::.||||||.||.||:|||||:||:|...|.:..:|   ..:.|:|||||||||||.|:.:.|.
Yeast    15 SHVTTPIFYPNAKPHLGHLYSSLLSDVYHRWQLFKG---NLSFFTTGTDEHGLKIQCASESNGFD 76

Human   109 APTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASD 173
            .|.:..|::..:|.||.:..||:.|.|||||:..|...|...|.:....|.:|.|.::|||..||
Yeast    77 QPKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLKNGYIYMGEHKGWYSISD 141

Human   174 ECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPF 238
            |.|.||:||.:.  |..|...::.||.:.|.:..|.||.||||.|.|.:...:|.||..|.|...
Yeast   142 ETFYPESKVIKD--PKNDGKYLNTESKNEVVYQSETNYFFRLSLFNKKIVDHIRKNPDFIFPASK 204

Human   239 HHVVLQWLDE--ELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIG---------- 291
            ...:|:.|:.  .|||||:||.|:.|.||||.|.|.||.:|||.|||.|||:.||
Yeast   205 RDQILKELETGGTLPDLSISRPSARLKWGIPTPNDPSQKVYVWFDALCNYLSSIGGIPSILSNAT 269

Human   292 --------------------YPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRIC 336
                                ||....::    |.|:|||||.|||.:|||:|||.||:..|::|.
Yeast   270 EVVSRHYSDKSNVKGQLLIPYPKEVQRN----TIHVIGKDIAKFHTVYWPSFLLAAGLPLPRQIV 330

Human   337 VHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELAD 401
            ||.||...|.||||||||||||......|..|..|:|||.......|.|:.:.|:.: ....|..
Yeast   331 VHGHWLCNGMKMSKSLGNVVDPIDMARYYGADIVRWFLLENSKLEEDGDFQEAKLYE-TRELLVS 394

Human   402 ALGGLLNRCTAKRINPSETYPAFCTTC-------FPSEPGLVGPSVRAQAEDYALVSAVATLPKQ 459
            ..|.|:|||...:.|.......|....       |.:|     |.|..:.|:      :|.|..:
Yeast   395 KWGNLINRCCGSKFNIERAVMKFSDKANFQFQEIFQNE-----PIVSERIEN------LAKLLNK 448

Human   460 VADHYDN----FRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVF 520
            ..:.:|.    |:..:.|..|.|.:...|..||...|    ||..:|..  ..::.:|:|..|:.
Yeast   449 SQEVFDEKIAIFQYPQLLRHVWSIINDANTLVQNSKP----WERELDQQ--DNIIFLAMETSRIL 507

Human   521 GTLLQPVTPSLADKLLSRLGVSASERS-----LGELYFLPRFYGHPCPFEGRRLGPETGLLFPRL 580
            ..|.|.:.|||:...|.|:.||..:|:     ||.    .:.||.....:||.: |...:.| ||
Yeast   508 SILCQSIIPSLSQSFLDRIDVSKEKRTINYARLGS----DKTYGKQSNKKGREV-PLKKIPF-RL 566

Human   581 DQSRT 585
            .:.:|
Yeast   567 QEEQT 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	MetG	44..581	CDD:439913	210/584 (36%)
		'HIGH' region	52..62		6/9 (67%)
		'KMSKS' region	347..351		3/3 (100%)
MSM1	NP_011687.1	metG	15..550	CDD:273058	205/565 (36%)