Protein Alignment MARS2 and MetRS-m

DIOPT Version :10

• Sequence 1: NP_612404.1
• Gene: MARS2 / 92935
• HGNCID: 25133
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_650348.1
• Gene: MetRS-m / 41733
• FlyBaseID: FBgn0027083
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 260/578 - (44%)
• Similarity: 353/578 - (61%)
• Gaps: 46/578 - (7%)

Human    17 RLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGP 81
            |:..|...|.||.||             .|.|||||||||||||||||||::|||.||::|||.|
  Fly     5 RIKCLRYLGTRYNSS-------------HYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYP 56

Human    82 STAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVA 146
            . ...|..|||||||.||||||:..|:...:.||.:|::::::|:.|.|...|||||||.||:.|
  Fly    57 E-QDVRLCTGTDEHGTKIQQAASLHGVPVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRA 120

Human   147 VQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENY 211
            |.:||..|.:||.:|...|.||||.|||.||.::::..... :|..:  ||||||||.||:|.||
  Fly   121 VANFWRTLHTRGHIYSAAYSGWYCVSDETFLTDSQLRLDEA-TGTRY--SLESGHPVEWTEETNY 182

Human   212 IFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTI 276
            :||||||:..::.|::...: :.|..|..::|..|.|.|||:||||.|:.:||.||||.|||||:
  Fly   183 MFRLSQFQDDVRHWVKTEAR-VRPAKFEKILLDTLSEPLPDVSVSRPSNRVHWAIPVPDDDSQTV 246

Human   277 YVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHW 341
            |||||||||||:.:|||:.:|.:.||....:|||||||||.|||.||||.||:.||.::.|||||
  Fly   247 YVWLDALVNYLSSVGYPDEKFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVHSHW 311

Human   342 TVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGL 406
            ||.|||||||..|||||.....:||::|.||||||:||.:.|.:|...|..::|||||||.||.|
  Fly   312 TVDGQKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYSHVKAQRILNSELADTLGNL 376

Human   407 LNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAE-----DYA--LVSAVATLPKQVADHY 464
            |:|.:||.:||.:.||:              ||....|:     |.|  |..::..|.::...||
  Fly   377 LSRASAKSLNPGQIYPS--------------PSAEHLADLLRSLDVAKRLQDSLLQLSERCESHY 427

Human   465 DNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESP-VDAPWLGTVLHVALECLRVFGTLLQPVT 528
            :....:...:...:.:...|.|.:...||.|...:| .:...|.|::.:.::.||:.|.:|||:.
  Fly   428 ECNHFHLVADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPII 492

Human   529 PSLADKLLSRLGVSASERS---LGELYFL-PRFYGHPCPF-EGRRL-GPETGLLFPRL 580
            |.||::||.:|.|..::|.   |.|.:.. |.....|... |.|:| |..:.|||.|:
  Fly   493 PQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQLDGQTSALLFQRI 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	MetG	44..581	CDD:439913	253/551 (46%)
		'HIGH' region	52..62		9/9 (100%)
		'KMSKS' region	347..351		3/3 (100%)
MetRS-m	NP_650348.1	MetG	21..559	CDD:439913	253/549 (46%)