DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MARS2 and TyrRS

DIOPT Version :9

Sequence 1:	NP_612404.1	Gene:	MARS2 / 92935	HGNCID:	25133	Length:	593	Species:	Homo sapiens
Sequence 2:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	73/380 - (19%)
Similarity:	128/380 - (33%)	Gaps:	110/380 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   233 ITPEPFHHVVLQWLDEELPDLSVSR----RSSHLHWGIPVPGDDSQTIYVWLDALVNYL------ 287
            |||.....::.:.|.|.|.|..:::    |...::||....|......:|.:..:.::|
  Fly     4 ITPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEV 68

Human   288 TVI-----GYPNAEFKSWWPATSHIIGKDILKFHAIYW----PAFLLGAGMSPPQRICVHSHWTV 343
            |::     .|.: ..|:.|         .:|:....|:    .|.|...|: |.:::..     |
  Fly    69 TILFADLHAYLD-NMKAPW---------SLLELRTKYYEQVIKAMLSSIGV-PLEKLKF-----V 117

Human   344 CGQ--KMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL--- 403
            .|.  ::||             .||:|.::   |...|...|......:|||.:...|...|
  Fly   118 KGSDYQLSK-------------EYTLDVYK---LSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYP 166

Human   404 ----------------GGLLNR---CTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAED--Y 447
                            ||:..|   ..:::..|...|........|..|||.|..:.:..||  .
  Fly   167 GLQALDEEYLKVDAQFGGVDQRKIFTFSEKYLPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKI 231

Human   448 ALVSAVATLPKQVADHY-------DNFRIYKALEAVSSCVRQTNGF-VQRHAPWK-----LNWES 499
            .|:.:.|.:.|::...:       ||..:......:.|..::..|| |.|.|...     |.:|.
  Fly   232 DLLDSPANVKKKLKKAFCEPGNIADNGLLSFVKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYED 296

Human   500 -----------PVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSA 543
                       |.|       |...:|  :....||.|:..:..:..|.:|..:|
  Fly   297 LEKYYAEDKLHPGD-------LKATVE--KYINRLLDPIRKAFENPELQKLSAAA 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	PRK11893	46..581	CDD:237012	73/380 (19%)
		'HIGH' region	52..62
		'KMSKS' region	347..351		1/3 (33%)
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	67/366 (18%)
		tyrS	12..332	CDD:272976	67/360 (19%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900