Protein Alignment MARS2 and MetRS

DIOPT Version :10

• Sequence 1: NP_612404.1
• Gene: MARS2 / 92935
• HGNCID: 25133
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_611382.1
• Gene: MetRS / 37177
• FlyBaseID: FBgn0034401
• Length: 1022
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 146/586 - (24%)
• Similarity: 232/586 - (39%)
• Gaps: 94/586 - (16%)

Human    48 TTPIFYVNAAPHIGHLYSALL-ADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPT 111
            |:.:.|||..||:|::...:| ||...|:.|..|.:|.   ...||||:|...:..|....|.|.
  Fly   259 TSALPYVNNVPHLGNIIGCVLSADIYARYSRSAGYNTL---LICGTDEYGTATENKALAENLTPR 320

Human   112 ELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQH-FWGVLKSRGLLYKGVYEGWYCASDEC 175
            |:||:..|....:::..||....|.|||.......||. |..|||:..::.:.| |...|...:.
  Fly   321 EICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESV-EQLLCQKCDR 384

Human   176 FLPEAKV---TQQPG-----PSGDSFP---------------VSLESGHPVSWTKEENYIFRLSQ 217
            ||.:..|   ...||     ..||...               ..:.:..||..:.::.:| .|.:
  Fly   385 FLADRFVEGTCPHPGCGYEDARGDQCDKCGKLVNATELIRPRCKVCNSAPVLRSSDQLFI-DLPK 448

Human   218 FRKPLQRWLRGNPQAITPEPFHH---VVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIY 277
            ....|:.|:..:....|    |:   :...||.|.|....::|   .|.||||||  |.:.:..|
  Fly   449 AEPQLKEWVDKSEGGWT----HNAKVITRAWLKEGLKPRCITR---DLKWGIPVPHEGFEKKVFY 506

Human   278 VWLDALVNYLTVIGYPNAEFKSWW-PATS------HIIGKDILKFHAIYWPAFLL--GAGMSPPQ 333
            ||.||...|:::......|::.|| ||..      ..:.||.:.||::.||:.||  ..|.:...
  Fly   507 VWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAINKGHTLVS 571

Human   334 RICVHSHWTVCGQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNS 397
            .|....:......|.|||.| .|............|.:|::|........|..:....:....||
  Fly   572 HIMATEYLNYEDGKFSKSRGIGVFGNDAQETGIPADVWRFYLASARPEGQDSSFSWNDLAARNNS 636

Human   398 ELADALGGLLNRCTAKRINPSETYPAFCTTCFPSE-PGLVGPSVRAQAEDYALVSAVATLPKQVA 461
            ||.:.||..:||..           .||...|.|. ||::      ..:|..::  :|.:.:::.
  Fly   637 ELLNNLGNFVNRAL-----------VFCEKNFSSTVPGVI------TTQDELVL--LALINRELR 682

Human   462 DHYDNFRIYKALEAVSSCV---RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL 523
            .:.::....|..:.|...:   |..||::|...||.|...:........|::.:.:....:...|
  Fly   683 GYINSMEKAKLRDGVRHLLAISRHGNGYMQSQQPWVLLKGTDDQKTRASTIIGLCVNIACLLANL 747

Human   524 LQPVTPSLADKLLSRLGVSA----SERSLGELYFLPRFY--GHPCPFEGRRLGPETGLLFPRLDQ 582
            |.|..|:.|..|..:|....    :|:.|..| .||..:  |.|.|            ||.:|:|
  Fly   748 LFPYMPTTARTLFGQLNAKQTPLNAEKPLVTL-LLPAGHQIGKPAP------------LFAKLEQ 799

Human   583 S 583
            |
  Fly   800 S 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	MetG	44..581	CDD:439913	143/582 (25%)
		'HIGH' region	52..62		5/9 (56%)
		'KMSKS' region	347..351		2/3 (67%)
MetRS	NP_611382.1	GST_N_5	1..70	CDD:436537
		GST_C_family	63..164	CDD:470672
		PLN02610	248..>850	CDD:215329	146/586 (25%)
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475