DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MARS2 and SPAC27E2.06c

DIOPT Version :9

Sequence 1:	NP_612404.1	Gene:	MARS2 / 92935	HGNCID:	25133	Length:	593	Species:	Homo sapiens
Sequence 2:	NP_594407.1	Gene:	SPAC27E2.06c / 2541577	PomBaseID:	SPAC27E2.06c	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	561	Identity:	223/561 - (39%)
Similarity:	312/561 - (55%)	Gaps:	63/561 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYF-TTPIFYVNAAPHIGHLY 64
            |||..:.||:.:...|                         ..:.|| ||||||||||||:||||
pombe     1 MLRKGICRLIHQVSES-------------------------SKKPYFLTTPIFYVNAAPHLGHLY 40

Human    65 SALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAG 129
            |.:|.||:.|.:.|: |..:... ||||||||||:|..|.|.|::|.:||||.|::|..|...|.
pombe    41 SLVLTDAIARFQNLK-PDVSVIS-STGTDEHGLKVQTVAQTEGVSPLQLCDRNSKRFADLAVAAN 103

Human   130 ISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGP-SGDSF 193
            ...|.|||||..:|:.:||.||..::..|::....:|||||.|||.|.||:.:.:...| :....
pombe   104 TKFTHFIRTTNPKHQASVQEFWKTIQKAGMISFERHEGWYCVSDETFYPESAIQKVVDPATKQEK 168

Human   194 PVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRR 258
            .||:|:|..|.|:.|.||.|.||:|:..|......||..:.|..||..||:.|...:.|||:||.
pombe   169 RVSMETGKEVQWSSEMNYHFLLSKFQSRLIEHYNKNPNFVQPSIFHTQVLEELKTGISDLSISRP 233

Human   259 SSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYP----NAEFKSWWPATSHIIGKDILKFHAIY 319
            ...|.|||||||:..||||||||||:||::|||||    .:...:.|||..|:|||||::||.||
pombe   234 KQRLSWGIPVPGNSQQTIYVWLDALINYISVIGYPWLNEKSSLSAGWPANMHVIGKDIIRFHCIY 298

Human   320 WPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDC 384
            |||||:.||:..|::|.||||||:...||||||||||||...:.:|.||..||:||::|....|.
pombe   299 WPAFLMAAGLPLPEKILVHSHWTMNKVKMSKSLGNVVDPFWLIEKYGVDTIRYYLLKRGRLTSDS 363

Human   385 DYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQ---AED 446
            ::..|::.|....:|..:||.||:|..:|::                   .:...::.|   .:|
pombe   364 NFDIEELEKDEEHDLRRSLGVLLSRLQSKKL-------------------FISNEIQKQWHKKDD 409

Human   447 YA----LVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLG 507
            :.    :|..:..||...|...|...:|:.:..|.|.:|:.....|...||||:.:|......|.
pombe   410 FTEYEDIVHELIELPVVCAQSIDGGCVYEVINLVQSVLRRVTKLFQLKEPWKLSDDSQEKIDTLM 474

Human   508 TVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSL 548
            .|.|    .||:.|.||||:.|:.:.:||.:||:..::|||
pombe   475 LVAH----SLRISGILLQPIMPTKSTELLDQLGIPKNQRSL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	PRK11893	46..581	CDD:237012	217/516 (42%)
		'HIGH' region	52..62		8/9 (89%)
		'KMSKS' region	347..351		3/3 (100%)
SPAC27E2.06c	NP_594407.1	MetG	15..539	CDD:223221	218/547 (40%)
		MetRS_core	20..365	CDD:173907	173/346 (50%)
		Anticodon_Ia_like	377..502	CDD:299868	37/147 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I194
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	392	1.000	Inparanoid score	I452
OMA	1	1.010	-	-		QHG54021
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto145991
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1450
SonicParanoid	1	1.000	-	-		X3534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860