Protein Alignment MARS2 and mars2

DIOPT Version :10

• Sequence 1: NP_612404.1
• Gene: MARS2 / 92935
• HGNCID: 25133
• Length: 593
• Species: Homo sapiens
• Sequence 2: XP_002940449.2
• Gene: mars2 / 100488527
• XenbaseID: XB-GENE-5862162
• Length: 571
• Species: Xenopus tropicalis
• Alignment Length: 590
• Identity: 299/590 - (50%)
• Similarity: 371/590 - (62%)
• Gaps: 40/590 - (6%)

Human     1 MLR-------TSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAY-FTTPIFYVNAA 57
            |||       |:::||..|.|::.                 :|..||...|.: :|||||||||:
 Frog    10 MLRFLPSRIFTNIVRLSSRCGSTE-----------------AANRDAVGTRPHLYTTPIFYVNAS 57

Human    58 PHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQ 122
            ||:||:|||||||...|:..:.|   ..:|.||||||||:|:||||:...|.|...|..||.||:
 Frog    58 PHLGHVYSALLADVQHRYSAMCG---IESRLSTGTDEHGMKVQQAASALSLDPHTFCSSVSLQFR 119

Human   123 QLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPG 187
            .:|.:..||.|||:||||.||:.||..||..|:.||.:|||.||||||.|||.||.|.:..::..
 Frog   120 NIFDDLDISYTDFVRTTEPRHKEAVSRFWMTLEERGYIYKGTYEGWYCTSDEAFLSEGQTAERID 184

Human   188 PSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPD 252
            ..|:...|||||||.|.|..||||:||||..|..|..||:..|  :.|.||..:|..||:|||||
 Frog   185 SEGNKIRVSLESGHQVHWVSEENYMFRLSSLRPALLNWLQTEP--VHPAPFLRLVHHWLEEELPD 247

Human   253 LSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHA 317
            |||||:.|.|.||||||.|.|..|||||||||||||..||||.:...|.|:| |::|||||:|||
 Frog   248 LSVSRQRSRLSWGIPVPSDSSHVIYVWLDALVNYLTAAGYPNLQLAPWGPST-HLLGKDILRFHA 311

Human   318 IYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNW 382
            |||||||:.||:|||.::.||||||..|.||||||.|||||..|:.|||.||.||:|||.|.|..
 Frog   312 IYWPAFLIAAGLSPPHKLLVHSHWTSEGTKMSKSLKNVVDPADCIRRYTKDGLRYYLLRHGAPER 376

Human   383 DCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDY 447
            |||:.......|||||||||||||||||||..|||.:.:|.|....|||         .|..:..
 Frog   377 DCDFTHRTARTLLNSELADALGGLLNRCTAPAINPMQHFPKFHYDSFPS---------AAHDQLQ 432

Human   448 ALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHV 512
            .:::.:..||.:|......|:::||||.:.:|||::|.|.|..|||||......:|....:|::|
 Frog   433 GVLANLQNLPAEVDQWVKKFQVHKALECIDACVRRSNAFFQSQAPWKLQRGVEKEAALRDSVIYV 497

Human   513 ALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLF 577
            .||.||::.|||||..|.||...|.||||....|:|....||....|..|.|:|:.||||.||||
 Frog   498 TLESLRLYATLLQPAVPGLATAALERLGVPLEMRTLKGNTFLAATRGESCYFQGQTLGPEKGLLF 562

Human   578 PRLDQ 582
            |||::
 Frog   563 PRLER 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARS2	NP_612404.1	MetG	44..581	CDD:439913	287/537 (53%)
		'HIGH' region	52..62		7/9 (78%)
		'KMSKS' region	347..351		3/3 (100%)
mars2	XP_002940449.2	MetG	43..566	CDD:439913	287/537 (53%)