Protein Alignment GPR52 and CG13579

DIOPT Version :9

• Sequence 1: NP_005675.3
• Gene: GPR52 / 9293
• HGNCID: 4508
• Length: 361
• Species: Homo sapiens
• Sequence 2: NP_001261169.1
• Gene: CG13579 / 37905
• FlyBaseID: FBgn0035010
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 104/476 - (21%)
• Similarity: 164/476 - (34%)
• Gaps: 169/476 - (35%)

Human    12 LNMSSGIVNVS---ERHSC--PLGFGHYSVVDVCIFET---VVIVLLTFLIIAGNLTVIFVF--- 65
            :::.:|.:.|:   :..||  |...||..:..:.|.||   |:|::||..:|..|..||||.
  Fly     1 MDLKTGSLLVAPAVKNSSCSHPRYSGHNFIAHIGIAETIEAVLILVLTLGVIGANCLVIFVINNR 65

Human    66 -HCAPLLHHYTTSYFIQTMAYADLFVGVSC----LVPTLSLLHYSTGVHESLTCQVFGYIISVLK 125
             :.|.:  |....|.:.::|..||.:|:..    |:|.|    :....:..:.||:...:...|.
  Fly    66 RYAAYI--HQQPRYLLTSLALNDLTIGLLITPFGLMPAL----FHCWPYGEIFCQIQALLRGALS 124

Human   126 SVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIF----LPS--FFG----- 179
            ..|...|.|::||||:....|..|.|..:.......:.|.||.|..:|    ||.  :|.
  Fly   125 QQSAVILVCMAVDRYMCALHPRRYYQHSSKKGCVAILSLTWIISLTVFGFLVLPKGYYFNNTGLM 189

Human   180 -----WGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTY---FHI--FKI----- 229
                 :.||.|.  |...||                ||.|...|:.:.|   ||:  |::
  Fly   190 ACEPFYSKPSYR--ILSTCA----------------LYFPTTMVLMYCYGSSFHMSRFRLNDPTM 236

Human   230 --------------------CRQHTKEINDRRA-----------RFPSH---------------- 247
                                .:.|..:.:.::|           ..|||
  Fly   237 PLTAAAHHPHPHPHPTAAQQLQMHQHQQHHQQAGMHSHLYHGHSHHPSHPSHPNHPNHHGHPHHH 301

Human   248 ----------------------------------EVDSSRETGHSPDRRYAMVLFRITSVFYMLW 278
                                              |.:||..|..|        :..|:..|.::.
  Fly   302 GPPVMGHLSMAMSMGLAGMPNMTNKITKKIVPIQEKNSSGSTSRS--------MAAISLGFIVMV 358

Human   279 LPYIIYFLLES---SRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCM 340
            .|:.|..::.:   |::  .|.|.||.||.|:|||..|..:|.|.||.||...|:|....|.
  Fly   359 TPWTIQEIVTACTGSKL--PPFLDFLVTWTALSNSLWNPFMYWLLNSDFRRMSRQLMPNKCF--- 418

Human   341 CVKDQEAQEPKPRKRANSCSI 361
                  ..|..|..::..|.|
  Fly   419 ------PHEDTPEHKSGCCHI 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR52	NP_005675.3	7tm_classA_rhodopsin-like	43..321	CDD:410626	85/398 (21%)
		TM helix 1	43..67	CDD:410626	12/30 (40%)
		TM helix 2	77..99	CDD:410626	7/25 (28%)
		TM helix 3	115..137	CDD:410626	5/21 (24%)
		TM helix 4	160..176	CDD:410626	6/19 (32%)
		TM helix 5	201..224	CDD:410626	5/25 (20%)
		TM helix 6	264..286	CDD:410626	4/21 (19%)
		TM helix 7	296..321	CDD:410626	13/24 (54%)
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	27/102 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910