DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAAR2 and ser-4

DIOPT Version :9

Sequence 1:	NP_001028252.1	Gene:	TAAR2 / 9287	HGNCID:	4514	Length:	351	Species:	Homo sapiens
Sequence 2:	NP_497452.1	Gene:	ser-4 / 175322	WormBaseID:	WBGene00004779	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	90/403 - (22%)
Similarity:	145/403 - (35%)	Gaps:	120/403 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    37 ERSLGVRVAMYSFMAGSIFITIFGNLAMIISISYFKQLH-TPTNFLILSMAITDFLLGFTIMPYS 100
            ||.|...|.:.|.:...|.....|||.:|::|...:.|. .|..:||.|:|:.|.|:|..:.|..
Worm    45 ERPLVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLG 109

Human   101 MIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYA---ICYPLLYSTK-ITIPVIK 161
            ...:|...|..|:..|..:.|.|:::...||.||.::|:||:::   |||....:.| ||:
Worm   110 AWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSITDICYVQNRTPKRITL---- 170

Human   162 RLLLLCWSVPGAFAFGVVFSEAYADG--IEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSM 224
             :|.:.|..      .::.|.|...|  .||:...|..|..|.:.....:........|:.|...
Worm   171 -MLAVIWFT------SLLISLAPFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIA 228

Human   225 MVGIYGKIFAVSRKH------------------------------------AHAINNLREN---- 249
            ::.:|.||...::|.                                    |..|::::.|
Worm   229 IICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKAMMPKKSKKCPLPPAVVISDIQANGGTG 293

Human   250 --------------------------------------------------------------QNN 252
                                                                          ::|
Worm   294 GKTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTTQETKIDEENGRSKPGIVKRRRRTKESN 358

Human   253 QVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGF 317
            ::|:::||.:||.|:.|.|:.||.|.|...:..|........||.....|.||.||..||:||..
Worm   359 EMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGCQISPVLEQVTLWLGYLNSALNPIIYTV 423

Human   318 FYPWFRRALKYIL 330
            |...||.|.|.|:
Worm   424 FSQDFRAAFKRII 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAAR2	NP_001028252.1	7tm_4	53..>180	CDD:304433	37/131 (28%)
TAAR2	NP_001028252.1	7tm_1	60..315	CDD:278431	76/363 (21%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	84/390 (22%)
		TM helix 1	53..79	CDD:320454	7/25 (28%)
		TM helix 2	87..113	CDD:320454	8/25 (32%)
		TM helix 3	125..155	CDD:320454	10/29 (34%)
		TM helix 4	166..188	CDD:320454	7/32 (22%)
		TM helix 5	210..239	CDD:320454	5/28 (18%)
		TM helix 6	361..391	CDD:320454	12/29 (41%)
		TM helix 7	400..425	CDD:320454	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910