DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR37L1 and CCHa1-R

DIOPT Version :9

Sequence 1:	NP_004758.3	Gene:	GPR37L1 / 9283	HGNCID:	14923	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	62/279 - (22%)
Similarity:	110/279 - (39%)	Gaps:	46/279 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   124 TESSY-------SAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLF 181
            ||:.|       ..|.:.:|..::|.||::||.:::.:......:::..|:.:.||||.|.||:.
  Fly    68 TETPYVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVII 132

Human   182 FCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRP----I 242
            ..:|:.......:....|...|....||:..|:||:.|:|.||..||:......|.|...    .
  Fly   133 TTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGR 197

Human   243 ERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQN 307
            ...:..||....||:.::...:|.|:...|..     :|..:.              |:|:.|..
  Fly   198 RATRMTLATAVSIWLLAILCGLPALIGSNLKH-----LGINEK--------------SIVICYPY 243

Human   308 ARMW----------WYFGCYFCLPI----LFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLN 358
            ...|          .:|..|:.:|:    :|.|...|........||...  .|.:..:...::.
  Fly   244 PEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQ--GAVRQVRARRKVA 306

Human   359 STVVGLTVVYAFCTLPENV 377
            .||:...|::..|.||.:|
  Fly   307 VTVLAFVVIFGICFLPYHV 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR37L1	NP_004758.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..108
		7tm_1	147..397	CDD:278431	54/249 (22%)
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	27/99 (27%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	54/249 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910