DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COPB2 and SEC27

DIOPT Version :9

Sequence 1:	NP_004757.1	Gene:	COPB2 / 9276	HGNCID:	2232	Length:	906	Species:	Homo sapiens
Sequence 2:	NP_011378.1	Gene:	SEC27 / 852740	SGDID:	S000003105	Length:	889	Species:	Saccharomyces cerevisiae

Alignment Length:	915	Identity:	399/915 - (43%)
Similarity:	581/915 - (63%)	Gaps:	67/915 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     3 LRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
            ::||||:..:.||||||.:|.||||||:|.:||:|.|.:||:|||..|::.:|.:.||||.||:|
Yeast     1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIA 65

Human    68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKW 132
            ||||::.|:||.:||||||||.|:|..||||.||||.||||||:|::|:.|||:.:|||:|:..|
Yeast    66 RKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW 130

Human   133 SCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EGHEKGVNCIDYYSG 196
            :..|.||||.|:||.:..||||.:.|||..||||:|||.||.|:||||| .|.|:|||.:|||..
Yeast   131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL 195

Human   197 GDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTY 261
            .||||:|:.:||..:||||||.|:||.|||||..|||.|.|||.|||||:||||||::||:||||
Yeast   196 PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTY 260

Human   262 RLESTLNYGMERVWCVAS--LRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIW-----AKH 319
            ::|.|||.|:||.||:|:  ....|.:|.|:|.|..::.||.:||.:|:|..||::|     |..
Yeast   261 KVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAA 325

Human   320 SEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALR 384
            |::..|.::  |:.|::..|.|.|..|::||.:::||::.|:||||||.|.|||||:||||:|.|
Yeast   326 SDIFTAVIR--GNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWR 388

Human   385 NKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFK-PDFGA-ESIYGGFLLGVRSVNGL 447
            ||:||..|:|.|..||:.||:.:....:|.:|||||..|:. |...| :.::.|.||||:|...:
Yeast   389 NKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFV 453

Human   448 AFYDWDNTELIRRIEIQPKHIFWSDSGELVCIAT------EESFFILKYLSEKVLAAQETHEGVT 506
            .|:||||..|:|||::..|.:.|||:||||.|..      |.|.:.|.:..:..|.|........
Yeast   454 YFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYTLLFNKDAYLEAANNGNIDD 518

Human   507 EDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDN 571
            .:|:::||:||.|:.|.:.:|.||||.||:|::.|||||:|||:...:||..:.||||||:.:||
Yeast   519 SEGVDEAFDVLYELSESITSGKWVGDVFIFTTATNRLNYFVGGKTYNLAHYTKEMYLLGYLARDN 583

Human   572 RLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMA-DKVLPTIP-KEQRTRVAHFLEKQGFKQQA 634
            ::||.|:|:::..|.:.:.|||:||..:|.:...| :.|||.:. |:..|::|.|||.|.:.::|
Yeast   584 KVYLADREVHVYGYEISLEVLEFQTLTLRGEIEEAIENVLPNVEGKDSLTKIARFLEGQEYYEEA 648

Human   635 LTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGL 699
            |.:|.|.:.:|||||::|:|.:|..|..:..:|.||:.|.:.::.:..|.||.|...:|.|...|
Yeast   649 LNISPDQDQKFELALKVGQLTLARDLLTDESAEMKWRALGDASLQRFNFKLAVEAFTNAHDLESL 713

Human   700 LLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTY--L 762
            .||.::..|...:..||:.|||.||.|:||.:|::.|.:....:|||::.|..|||||..||  .
Yeast   714 FLLHSSFNNKEGLVTLAKDAERAGKFNLAFNAYWIAGDIQGAKDLLIKSQRFSEAAFLGSTYGLG 778

Human   763 PSQVSRVVKLWRENL-----SKVNQK--AAESLADPTEYENLFPGL--------------KEAFV 806
            ...|:.:|..|:|||     :.|:::  .||.|...:...:..|.:              |||.|
Yeast   779 DDAVNDIVTKWKENLILNGKNTVSERVCGAEGLPGSSSSGDAQPLIDLDSTPAPEQADENKEAEV 843

Human   807 VEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDFQPSRSTAQQELDGKPASPTPVIVASHTAN 871
            .:...||:               |.|....|:.::..|.:..::|:.:...|.|.||
Yeast   844 EDSEFKES---------------NSEAVEAEKKEEEAPQQQQSEQQPEQGEAVPEPV-------- 885

Human   872 KEEKS 876
             ||:|
Yeast   886 -EEES 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COPB2	NP_004757.1	WD40	8..297	CDD:238121	172/291 (59%)
		WD 1	13..52		24/38 (63%)
		WD40 repeat	19..55	CDD:293791	19/35 (54%)
		WD40	24..428	CDD:225201	224/412 (54%)
		WD 2	55..94		25/38 (66%)
		WD 3	97..136		22/38 (58%)
		WD40 repeat	103..140	CDD:293791	19/36 (53%)
		WD 4	140..180		24/39 (62%)
		WD40 repeat	145..182	CDD:293791	24/37 (65%)
		WD 5	183..224		24/40 (60%)
		WD40 repeat	189..226	CDD:293791	21/36 (58%)
		WD 6	227..266		27/38 (71%)
		WD40 repeat	232..268	CDD:293791	25/35 (71%)
		Coatomer_WDAD	320..763	CDD:281977	185/454 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..870		7/32 (22%)
SEC27	NP_011378.1	WD40	6..293	CDD:238121	170/286 (59%)
		WD40 repeat	19..53	CDD:293791	18/33 (55%)
		WD40 repeat	59..95	CDD:293791	23/35 (66%)
		WD40 repeat	100..137	CDD:293791	19/36 (53%)
		WD40 repeat	144..180	CDD:293791	22/35 (63%)
		WD40 repeat	187..225	CDD:293791	22/37 (59%)
		WD40 repeat	231..267	CDD:293791	25/35 (71%)
		WD40 repeat	316..351	CDD:293791	9/36 (25%)
		Coatomer_WDAD	326..777	CDD:397941	185/452 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159047444
Domainoid	1	1.000	362	1.000	Domainoid score	I145
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	771	1.000	Inparanoid score	I73
Isobase	1	0.950	-	0	Normalized mean entropy	S403
OMA	1	1.010	-	-		QHG53763
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto144691
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R226
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740