DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COPB2 and copb2

DIOPT Version :9

Sequence 1:	NP_004757.1	Gene:	COPB2 / 9276	HGNCID:	2232	Length:	906	Species:	Homo sapiens
Sequence 2:	NP_001027518.1	Gene:	copb2 / 613110	XenbaseID:	XB-GENE-964668	Length:	920	Species:	Xenopus tropicalis

Alignment Length:	920	Identity:	823/920 - (89%)
Similarity:	860/920 - (93%)	Gaps:	14/920 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog     1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65

Human    66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog    66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130

Human   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195

Human   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSST 260
            |||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||
Frog   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCVSFHPELPIIITGSEDGTVRIWHSST 260

Human   261 YRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQA 325
            |||||||||||||||||:.||||||||||||||||||||||||||||||||||||||||||:|||
Frog   261 YRLESTLNYGMERVWCVSGLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEIQQA 325

Human   326 NLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGS 390
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   326 NLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGS 390

Human   391 AQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNT 455
            ||||||||||||||||||||:||||||||||||||||||||.||||||||||||||||||||:||
Frog   391 AQEFAWAHDSSEYAIRESNSLVKIFKNFKEKKSFKPDFGAEGIYGGFLLGVRSVNGLAFYDWENT 455

Human   456 ELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEI 520
            ||||||||||||||||||||||||||||||||||||||||..||||||||:||||||||||||||
Frog   456 ELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVATAQETHEGVSEDGIEDAFEVLGEI 520

Human   521 QEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISY 585
            ||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||:||
Frog   521 QEIVKTGLWVGDCFIYTSTVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSY 585

Human   586 SLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQ 650
            ||||||||||||||||||||||||:|||||||||||||||||||||||||.||||||||||||||
Frog   586 SLLVSVLEYQTAVMRRDFSMADKVIPTIPKEQRTRVAHFLEKQGFKQQALAVSTDPEHRFELALQ 650

Human   651 LGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKL 715
            |||||||||||||||||||||||||||||||||||||||||.||||||||||||:||||.|||||
Frog   651 LGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHSAQDYGGLLLLATSSGNATMVNKL 715

Human   716 AEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKV 780
            |||||:||||||||:||||.||:|:||||||.||||||||||||||||||||||||||:|:|.||
Frog   716 AEGAEKDGKNNVAFLSYFLLGKLDSCLELLISTGRLPEAAFLARTYLPSQVSRVVKLWKESLGKV 780

Human   781 NQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDFQPS 845
            |||||:||||||.||||||||:||:..|.::|:....|.|||:|..||||||||::.|.|.|.||
Frog   781 NQKAADSLADPTAYENLFPGLREAYAAEPFLKQNSGILLPAKEYRHVTPNEERNILSEAKGFDPS 845

Human   846 RS---TAQQELDGKP--------ASPTPVIVASH---TANKEEKSLLELEVDLDNLELEDIDTTD 896
            .|   ..::|....|        |.|:|.|.|..   ..:..:|:|.:||.||||:||:||||||
Frog   846 ESAFTAVEKESVEVPNQAVPIPFAVPSPSIPAPEMPAPKSSMDKALFDLEEDLDNMELDDIDTTD 910

Human   897 INLDEDILDD 906
            ||||:::.|:
Frog   911 INLDDELSDE 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COPB2	NP_004757.1	WD40	8..297	CDD:238121	285/288 (99%)
		WD 1	13..52		38/38 (100%)
		WD40 repeat	19..55	CDD:293791	35/35 (100%)
		WD40	24..428	CDD:225201	397/403 (99%)
		WD 2	55..94		38/38 (100%)
		WD 3	97..136		38/38 (100%)
		WD40 repeat	103..140	CDD:293791	36/36 (100%)
		WD 4	140..180		39/39 (100%)
		WD40 repeat	145..182	CDD:293791	36/36 (100%)
		WD 5	183..224		40/40 (100%)
		WD40 repeat	189..226	CDD:293791	36/36 (100%)
		WD 6	227..266		37/38 (97%)
		WD40 repeat	232..268	CDD:293791	34/35 (97%)
		Coatomer_WDAD	320..763	CDD:281977	421/442 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..870		13/46 (28%)
copb2	NP_001027518.1	Coatomer_WDAD	319..763	CDD:367786	422/443 (95%)
		WD40	8..297	CDD:238121	285/288 (99%)
		WD40 repeat	19..55	CDD:293791	35/35 (100%)
		WD40 repeat	103..140	CDD:293791	36/36 (100%)
		WD40 repeat	145..182	CDD:293791	36/36 (100%)
		WD40 repeat	189..226	CDD:293791	36/36 (100%)
		WD40 repeat	232..262	CDD:293791	28/29 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	855	1.000	Domainoid score	I1025
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1664	1.000	Inparanoid score	I1092
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto148804
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080