DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COPB2 and copb2

DIOPT Version :9

Sequence 1:	NP_004757.1	Gene:	COPB2 / 9276	HGNCID:	2232	Length:	906	Species:	Homo sapiens
Sequence 2:	NP_001001940.1	Gene:	copb2 / 114454	ZFINID:	ZDB-GENE-010724-7	Length:	934	Species:	Danio rerio

Alignment Length:	939	Identity:	817/939 - (87%)
Similarity:	862/939 - (91%)	Gaps:	38/939 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65
            |||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||:||
Zfish     1 MPLRLDIKRKLTARSDRVKSVDLHPSEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRASKF 65

Human    66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
            |||||||:|||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|
Zfish    66 VARKNWVITGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPYILTSSDDMLIKLWDWEK 130

Human   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Zfish   131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHDKGVNCIDYYS 195

Human   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSST 260
            |||||||||||||||||||||||||||||||||||||||.:||||||||||||||||||||||||
Zfish   196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCVNFHPELPIIITGSEDGTVRIWHSST 260

Human   261 YRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQA 325
            |||||||||||||||||:.|||||:|||||||||||:||||||||||||.|||||||||||:|||
Zfish   261 YRLESTLNYGMERVWCVSGLRGSNSVALGYDEGSIIIKLGREEPAMSMDTNGKIIWAKHSEIQQA 325

Human   326 NLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   326 NLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGS 390

Human   391 AQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNT 455
            ||||.|||||||||||||:|:||||||||||||||||||||.||||||||||||||||||||:||
Zfish   391 AQEFVWAHDSSEYAIRESSSVVKIFKNFKEKKSFKPDFGAEGIYGGFLLGVRSVNGLAFYDWENT 455

Human   456 ELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEI 520
            |||||||||||||||||||||||||||||||||:||||||.|:||.:||||||||||||||||||
Zfish   456 ELIRRIEIQPKHIFWSDSGELVCIATEESFFILRYLSEKVAASQENNEGVTEDGIEDAFEVLGEI 520

Human   521 QEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISY 585
            ||:||||||||||||||||||||||:||||||||||||||||||||||||:|||||||||||:||
Zfish   521 QEVVKTGLWVGDCFIYTSSVNRLNYFVGGEIVTIAHLDRTMYLLGYIPKDDRLYLGDKELNIVSY 585

Human   586 SLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQ 650
            ||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||||||||||
Zfish   586 SLLVSVLEYQTAVMRRDFGMADKVLPTIPKEQRTRVAHFLEKQGFKQQALAVSTDPEHRFELALQ 650

Human   651 LGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKL 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||.||
Zfish   651 LGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNASMVAKL 715

Human   716 AEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKV 780
            |||||||||||||||:||||||:|.||||||:|.||||||||||||||||||||||||||:||||
Zfish   716 AEGAERDGKNNVAFMTYFLQGKLDNCLELLIKTNRLPEAAFLARTYLPSQVSRVVKLWRESLSKV 780

Human   781 NQKAAESLADPTEYENLFPGLKEAFVVEEWVKETH-ADLWPAKQYPLVTPNEERNVMEEGKDFQP 844
            |||||||||||||||||||||:||||.|:::|||. ....||..|||:||||||||:||...::|
Zfish   781 NQKAAESLADPTEYENLFPGLREAFVAEQYLKETSLGQTRPASDYPLITPNEERNVLEEASGYEP 845

Human   845 ----------------------------SRSTAQQE----LDGKPASPTPVIVASHTANKEEKSL 877
                                        :.|:||.:    |..|....||.|.|:     |:|.:
Zfish   846 KGILPAPTQLKQEVSEDEEVLASVSSVSAVSSAQSQPDPKLQEKTEEKTPEITAA-----EQKVI 905

Human   878 LELEVDLDNLELEDIDTTDINLDEDILDD 906
            .|||.||||:|.:||||||:|||:..:||
Zfish   906 DELEDDLDNMEFDDIDTTDVNLDDGYVDD 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COPB2	NP_004757.1	WD40	8..297	CDD:238121	277/288 (96%)
		WD 1	13..52		37/38 (97%)
		WD40 repeat	19..55	CDD:293791	34/35 (97%)
		WD40	24..428	CDD:225201	386/403 (96%)
		WD 2	55..94		36/38 (95%)
		WD 3	97..136		36/38 (95%)
		WD40 repeat	103..140	CDD:293791	34/36 (94%)
		WD 4	140..180		39/39 (100%)
		WD40 repeat	145..182	CDD:293791	36/36 (100%)
		WD 5	183..224		39/40 (98%)
		WD40 repeat	189..226	CDD:293791	36/36 (100%)
		WD 6	227..266		36/38 (95%)
		WD40 repeat	232..268	CDD:293791	33/35 (94%)
		Coatomer_WDAD	320..763	CDD:281977	418/442 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..870		12/64 (19%)
copb2	NP_001001940.1	WD40	8..297	CDD:238121	277/288 (96%)
		WD40 repeat	19..55	CDD:293791	34/35 (97%)
		WD40	24..428	CDD:225201	386/403 (96%)
		WD40 repeat	103..140	CDD:293791	34/36 (94%)
		WD40 repeat	145..182	CDD:293791	36/36 (100%)
		WD40 repeat	189..226	CDD:293791	36/36 (100%)
		WD40 repeat	232..262	CDD:293791	27/29 (93%)
		Coatomer_WDAD	320..763	CDD:281977	418/442 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328138
Domainoid	1	1.000	850	1.000	Domainoid score	I700
eggNOG	1	0.900	-	-		E1_KOG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3499
Inparanoid	1	1.050	1641	1.000	Inparanoid score	I740
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53763
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0003151
OrthoInspector	1	1.000	-	-		oto49436
orthoMCL	1	0.900	-	-		OOG6_101404
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2116
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270