DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNER and dner

DIOPT Version :9

Sequence 1:	NP_620711.3	Gene:	DNER / 92737	HGNCID:	24456	Length:	737	Species:	Homo sapiens
Sequence 2:	NP_001269415.1	Gene:	dner / 100332110	ZFINID:	ZDB-GENE-130502-1	Length:	744	Species:	Danio rerio

Alignment Length:	744	Identity:	422/744 - (56%)
Similarity:	523/744 - (70%)	Gaps:	28/744 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    17 LALLLLLLGA--GPRGSSL-ANPVPAA-PLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAG--E 75
            |.|||||||.  |..|:.| ::|.|.. |.:||.||..:||.|||||:...|.:........  |
Zfish     6 LPLLLLLLGEMDGLFGTPLTSSPGPGEDPSTAPDPCEGRPCLNGGVCSRLGEMEDSQSTQMQTLE 70

Human    76 P-GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPS- 138
            | .|.|.|..|.:|.||:..||||||:||.||||  |.....:|:.|.|:|||.|..|:  ||:
Zfish    71 PWAYICVCSRGFTGQNCEFFADPCASSPCLHGNC--SQDGEGEGFTCECSEGYSGARCD--LPTL 131

Human   139 ---LPATGW--TESMAPRQLQP----VPATQ----EPDKILPRSQATVTLPTWQPKTGQKVVEMK 190
               |..:.|  .||:.|....|    .|||.    :|..:|..:||..||..|||:.||:|:|:.
Zfish   132 TFDLSESTWDLAESLVPEHATPATPATPATTTQVLQPTTVLTTTQAPPTLEPWQPRAGQRVLEIL 196

Human   191 WDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDG 255
            ||..::..:..|.:.:...|||...:|.|:.:.|:||:..:.:.|.: ||:|.|:|::|||:.||
Zfish   197 WDDQQITNEAECVSTAGGESAGMMSISLELAEETAVKLVGNVSGSAV-LWRVGASGYEQCSVADG 260

Human   256 RSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECS 320
            ..:...|:|.||||.::.|.||:|:||..:..|.:...|.|||.|:||.:.|:...|..:|.:||
Zfish   261 TIMWFQQSSEGLVLPDQSLPLGHNYFITLLVGSPSGPEVTLRLHLLVKTNNCMEPGSAFSDPQCS 325

Human   321 GKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYT 385
            |||||.|:.|..||.|.|::.|.|.||||:|||..|||:||.||.|..::.:|.|:||.|..|:.
Zfish   326 GKGKCVTQSSVDTFYCRCDDGYSGIFCEEFDACHLKPCENNGSCADLRQRDEGQNYTCTCQTGFE 390

Human   386 GELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVD-- 448
            ||.|||.:|:|:..||||||||.|||.|..|.|.|||.|..||:|:|||||.||.||.:|...
Zfish   391 GERCQSLVDHCVSGPCRNGATCSSSLEGPHCYCAEGYQGIMCEQKIDPCASGPCHNNASCSPQGA 455

Human   449 GVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAP 513
            |:.|:|.|..||||||||||:|||||:|||||.|||:||||:|||.|||||||||||||||||||
Zfish   456 GLGFSCTCPAGFTGPTCAQLVDFCALNPCAHGICRSIGTSYRCLCVPGYHGLYCEEEYNECLSAP 520

Human   514 CLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEEC 578
            |.|.||||||:|.|||:|.:::.|.|||:|||||..:.|.||..|:|.|.|.:|:|.||:.||.|
Zfish   521 CQNYATCRDLINAYECICASQFTGKHCEIYKDPCLKLRCQNGGHCESGGRNASCVCPPGYMGENC 585

Human   579 DIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIII 643
            ::|:|||:||||||||:|:||.|||.||||.||||.:||||||||.....:||||||||||||||
Zfish   586 EVDVNECESNPCHHGGTCIDQSNGYTCHCPPGWVGGSCEIHLQWKMAQPVDSLTNMPRHSLYIII 650

Human   644 GALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRP 708
            |||||||:|||||||||||||||||||||||.||:||||||||||:|||||||||||||||||||
Zfish   651 GALCVAFVLMLIILIVGICRISRIEYQGSSRHAYQEFYNCRSIDSDFSNAIASIRHARFGKKSRP 715

Human   709 AMYDVSPIAYEDYSPDDKPLVTLIKTKDL 737
            ||||.:||:||||||||||||.|||||||
Zfish   716 AMYDATPISYEDYSPDDKPLVALIKTKDL 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNER	NP_620711.3	Interaction with NOTCH1. /evidence=ECO:0000250	44..133		41/91 (45%)
		EGF_CA	393..428	CDD:238011	20/34 (59%)
		EGF_CA	431..465	CDD:238011	19/35 (54%)
		EGF_CA	469..503	CDD:238011	27/33 (82%)
		EGF_CA	507..541	CDD:238011	22/33 (67%)
		EGF_CA	581..617	CDD:238011	26/35 (74%)
		Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000250	677..680		1/2 (50%)
dner	NP_001269415.1	PHA03099	<99..>126	CDD:165381	13/28 (46%)
		EGF_CA	398..433	CDD:238011	20/34 (59%)
		EGF_CA	436..472	CDD:238011	19/35 (54%)
		EGF_CA	476..510	CDD:238011	27/33 (82%)
		EGF_CA	514..548	CDD:238011	22/33 (67%)
		EGF_CA	<559..586	CDD:238011	13/26 (50%)
		EGF_CA	588..624	CDD:238011	26/35 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324892
Domainoid	1	1.000	225	1.000	Domainoid score	I11087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26722
Inparanoid	1	1.050	882	1.000	Inparanoid score	I2944
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48172
OrthoDB	1	1.010	-	-		D199127at33208
OrthoFinder	1	1.000	-	-		FOG0008370
OrthoInspector	1	1.000	-	-		oto49054
orthoMCL	1	0.900	-	-		OOG6_114316
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6356
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.310