DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYTH2 and sec73

DIOPT Version :9

Sequence 1:	XP_006723535.1	Gene:	CYTH2 / 9266	HGNCID:	9502	Length:	421	Species:	Homo sapiens
Sequence 2:	NP_001342851.1	Gene:	sec73 / 3361502	PomBaseID:	SPAC19A8.01c	Length:	1082	Species:	Schizosaccharomyces pombe

Alignment Length:	291	Identity:	80/291 - (27%)
Similarity:	133/291 - (45%)	Gaps:	44/291 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     2 DPVVRITRSPATSPV-MESENQGLSPLPKPPDLTPE-ERMELENIRRRKQELLVEIQRLREELSE 64
            |.:..:.:|..||.| ..|.:.|...|.:.|.:..: |:.:.::.|.|.:...:..||..|.|.|
pombe   245 DYIKPVDKSDQTSNVPSPSSSVGSLRLYRSPSIPNDVEQPQPQSSRSRPRSSTIPTQRTLERLRE 309

Human    65 AMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEN------------ELLQNTPEE 117
            ..|.:...      :||:|             |..:.:...:||            :.|.:.||.
pombe   310 NRSSIFSF------RTLRR-------------DDDECVAQTIENSALFSDIKPNPTKFLSSVPEL 355

Human   118 IA-----RFLYK-GEGLNKTAIGDYLGEREELNL-AVLHAFVDLHEFTDLNLVQALRQFLWSFRL 175
            .|     .:|.| .|.:..:.:...|.|::.:.| ..||..:...||.:..|...||.||....|
pombe   356 TADDTAESYLSKLRETVPYSRMIPVLAEKDHVTLNKALHLCMSGMEFENRPLDFCLRLFLLKSHL 420

Human   176 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR 240
            |.|.|:|||::.||::||..||||:|.|.|.||:|.|:::||:|.:.|.|.:.|...:.|:
pombe   421 PKETQQIDRVINAFSKRYFECNPGMFSSQDQCYILVFSLMMLHTDVFNSNNKHKMTKQEFI---- 481

Human   241 GINEGGDLPEELLRNLYDSIRNEPFKIPEDD 271
            .:.:..:|..|::...||:|...||...:|:
pombe   482 NLCDIDELAPEIMEYYYDNITFTPFVNLDDE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYTH2	XP_006723535.1	Sec7	83..265	CDD:396096	57/200 (29%)
CYTH2	XP_006723535.1	PH_GRP1-like	280..399	CDD:269954
sec73	NP_001342851.1	COG3942	5..>222	CDD:332523
		Sec7	<381..506	CDD:307500	46/128 (36%)
		PH	<710..767	CDD:214574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000