DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYTH2 and SPBC211.03c

DIOPT Version :9

Sequence 1:	XP_006723535.1	Gene:	CYTH2 / 9266	HGNCID:	9502	Length:	421	Species:	Homo sapiens
Sequence 2:	NP_596613.1	Gene:	SPBC211.03c / 2540746	PomBaseID:	SPBC211.03c	Length:	1462	Species:	Schizosaccharomyces pombe

Alignment Length:	292	Identity:	85/292 - (29%)
Similarity:	139/292 - (47%)	Gaps:	33/292 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    51 LLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRK----MAMGRKKFNMDPKKGIQFLVENELL 111
            ||..|....|.|....::......::.:|||..::|    :..|.:.||..|..||.||.::.::
pombe   512 LLNFIYYFHEHLQPCYNDPNNTFKDDVAKTLIESKKRKAIIIEGAELFNESPSDGIAFLTQHSII 576

Human   112 Q--NTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFR 174
            :  :.|..|..|.:....|:|..:|::|.:..  |..:|:||:...:|....:.:|||..|.|||
pombe   577 KQSDNPTCIVEFFHSTNRLSKRVLGEFLTKGS--NSHILNAFISAFDFKGKRIDEALRLLLQSFR 639

Human   175 LPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVA 237
            ||||:|.|:|::|.|:..|...||....|.|..:|||:::|||||..||||::.  :..|:.|..
pombe   640 LPGESQLIERVLETFSHYYMSANPDSMSSKDAAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCR 704

Human   238 MNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVK---TWK 299
            ..||:|:|.|.....|..:|.:|:.....:.|:...:|:..:.      | .||...||   .:|
pombe   705 NVRGVNDGQDFDRNFLSEIYKAIKENEIIVAEEHDTELSFLYI------W-SKLQQSVKITEPFK 762

Human   300 RR-------------WFILTDNCLYYFEYTTD 318
            |.             |..:....:|.|...|:
pombe   763 RSSSNVHDKIVFLEVWKSIMAALIYVFSTATE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYTH2	XP_006723535.1	Sec7	83..265	CDD:396096	64/189 (34%)
CYTH2	XP_006723535.1	PH_GRP1-like	280..399	CDD:269954	11/55 (20%)
SPBC211.03c	NP_596613.1	Sec7_N	287..475	CDD:289549
		COG5307	289..1303	CDD:227623	85/292 (29%)
		Sec7	548..732	CDD:279680	63/185 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910