DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STK17A and CG10177

DIOPT Version :9

Sequence 1:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	74/259 - (28%)
Similarity:	115/259 - (44%)	Gaps:	20/259 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    69 RGKFAVVR-KCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETAS 132
            ||:....| ||         ..|.:.|:.:..| |.:...|..||...|.:|.:|.|....|...
  Fly   165 RGQTRANRTKC---------TVKMVNKQTQSND-RGDTYMEAEVLRQLQSHPNIIELMYTVEDER 219

Human   133 EMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSE 197
            .|..|||:.   :...|.|..:.....|.|.:.:||..:..:..:|...|:|.|:||:|:|:.|.
  Fly   220 YMYTVLEHL---DCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSS 281

Human   198 SPLGD---IKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTG 259
            |...:   :|:.:|.|:...:.| :|....|||.|:|||:::........|.||:||..:.||.|
  Fly   282 SGKWNFKMVKVANFDLATYYRGS-KLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCG 345

Human   260 ISPFLG--NDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321
            ..||..  .:.:|.:..|.....:|.::...|:|..|...|..|||..|..|....|..|..:|
  Fly   346 KMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAELDKFQFL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		STKc_DRAK1	51..321	CDD:271099	73/257 (28%)
		S_TKc	64..321	CDD:214567	73/257 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	73/257 (28%)
		PKc_like	164..403	CDD:304357	71/251 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900