DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STK17A and stk17a

DIOPT Version :9

Sequence 1:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_001082806.1	Gene:	stk17a / 327345	ZFINID:	ZDB-GENE-030131-5556	Length:	367	Species:	Danio rerio

Alignment Length:	374	Identity:	254/374 - (67%)
Similarity:	297/374 - (79%)	Gaps:	31/374 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    41 GLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEI 105
            |||.|||..:|:|||.:.|.:.||:|||||||||||||::|.||||||||:|||||||||||.||
Zfish    25 GLLREIRTAIRSEPFTERYDVIPGKELGRGKFAVVRKCVEKSSGKEFAAKYMRKRRKGQDCRTEI 89

Human   106 IHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQI 170
            ||||||||||...|.|:|||||||..|||:||||||||||||:||||||:|||.|::|:|||:||
Zfish    90 IHEIAVLELAAACPRVVNLHEVYEMPSEMVLVLEYAAGGEIFNQCVADRDEAFTEQEVKRLMKQI 154

Human   171 LEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEIL 235
            ||||.|||..:|||||||||||||||||||||||||||||||:|.||.|:|||||||||||||:|
Zfish   155 LEGVSFLHNNNVVHLDLKPQNILLTSESPLGDIKIVDFGLSRLLSNSHEVREIMGTPEYVAPEVL 219

Human   236 SYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT 300
            :|:|||.||||||||||.||||||||||||:|||||||||||:|:||||||.:.|..||:.||::
Zfish   220 NYEPISTATDMWSIGVLVYVMLTGISPFLGDDKQETFLNISQINISYSEEELEHLDGSAIRFIKS 284

Human   301 LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESI 365
            ||:|:||:|||||:||||.||              ..||.:.::.  ||....|..|:.|
Zfish   285 LLIKEPENRATAEDCLKHQWL--------------QTEEQDLIES--SVSPGTSSPDEEE----- 328

Human   366 VTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY 414
             .|||||:.:||||||||:.    |||.:|||||||     |:.|:|||
Zfish   329 -EEELIVMAAYTLGQCRQTP----EQKDVSKRFKFE-----ELSGDFIY 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		STKc_DRAK1	51..321	CDD:271099	211/269 (78%)
		S_TKc	64..321	CDD:214567	205/256 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		5/20 (25%)
stk17a	NP_001082806.1	PKc_like	35..305	CDD:304357	211/269 (78%)
stk17a	NP_001082806.1	S_TKc	48..305	CDD:214567	205/256 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325082
Domainoid	1	1.000	422	1.000	Domainoid score	I4114
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55846
Inparanoid	1	1.050	487	1.000	Inparanoid score	I6677
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48020
OrthoDB	1	1.010	-	-		D1156450at2759
OrthoFinder	1	1.000	-	-		FOG0004726
OrthoInspector	1	1.000	-	-		oto48754
orthoMCL	1	0.900	-	-		OOG6_106249
Panther	1	1.100	-	-	LDO	PTHR24342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4829
SonicParanoid	1	1.000	-	-		X3322
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300