DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STK17B and cmk1

DIOPT Version :9

Sequence 1:	NP_004217.1	Gene:	STK17B / 9262	HGNCID:	11396	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_593464.1	Gene:	cmk1 / 2542442	PomBaseID:	SPACUNK12.02c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	267	Identity:	94/267 - (35%)
Similarity:	137/267 - (51%)	Gaps:	20/267 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    39 LGRGKFAVVRQCISKSTGQEYAAKFLKKR--RRGQDCRAEILHEIAVLE-LAKSCPRVINLHEVY 100
            ||.|.:|.||:.:...|.:.||||.:.|:  .:.||.   :.:|||:|: ::...|.:::|.:.:
pombe    37 LGGGTYATVREAVHIETNKMYAAKIMNKKMMEKKQDF---VKNEIAILKRVSYEHPNILHLVDFF 98

Human   101 ENTSEIILILEYAAGGEIFS-LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNI 164
            |..:.:.||.|.|.|||:|. :|   ......|.|...|::.....|.|||.|.|||.||||:|:
pombe    99 ETVNNLYLITELATGGELFDRIC---AKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKPENL 160

Human   165 LLSSIYPLGDIKIVDFGMSRKIGHACE------LREIMGTPEYLAPEILNYDPITTATDMWNIGI 223
            |..|..|..|:.|.|||:|    |..|      |....|||||:|||:..........|||.||:
pombe   161 LYRSKDPNSDLLIADFGLS----HFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGV 221

Human   224 IAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICL 288
            |.|.||:..:||......|....|......:::..:|.:|:.|.|||:..|..:|.||.||...|
pombe   222 ITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADAL 286

Human   289 SHSWLQQ 295
            .|.:|.:
pombe   287 KHPFLSE 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK17B	NP_004217.1	STKc_DRAK2	24..293	CDD:271100	93/263 (35%)
STK17B	NP_004217.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..362
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	93/262 (35%)
cmk1	NP_593464.1	S_TKc	31..291	CDD:214567	93/263 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810