Protein Alignment CACNA2D2 and CG4587

DIOPT Version :9

• Sequence 1: XP_011532545.1
• Gene: CACNA2D2 / 9254
• HGNCID: 1400
• Length: 1151
• Species: Homo sapiens
• Sequence 2: NP_001188817.2
• Gene: CG4587 / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Alignment Length: 1337
• Identity: 317/1337 - (23%)
• Similarity: 528/1337 - (39%)
• Gaps: 387/1337 - (28%)

Human    70 MQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQAL 134
            :::||.:...::....|.|..:.:::..:|||.  .||:..:...|:.::|.::::.:|.|..|:
  Fly    39 VRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDFKRNAV 101

Human   135 KRLADAAENFQKAHRWQDNIKEEDI---VYYDAK------ADAELDDPESEDVERGSKASTLRLD 190
            .||.|:||....:........|..:   .:|||:      ||.:|.|        |::...:|
  Fly   102 MRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLAD--------GARHMDIR-- 156

Human   191 FIEDPNFKN-KVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSAT 254
            |:.  .|:. .||.|.:::.:|..:......:.:.|.|:..|:.:|..|..|||.|.||.|||:|
  Fly   157 FMR--RFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSST 219

Human   255 GVTRYYPATPW-----RAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSV 314
            |..|.:|.|.|     :..|.|  :|.|...|::|.||||||::|::|.|.|::..:..|...:.
  Fly   220 GFLRRFPGTAWPPEGSKGSKLI--HDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATA 282

Human   315 CEMLDTLSDDDYVNVASFNEKAQ-PVSCF-THLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEY 377
            ..:||||.:||:||:.:|:|..: ||.|| ..:|:|...|.:..|.||:.:..:.|..:.||.||
  Fly   283 FNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEY 347

Human   378 AFDQLQNSNITRA--NCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQW 440
            ||..|...|.:.|  .||:.||:.|:...:..:||.::||||:..||:||:.:|..:...:.|..
  Fly   348 AFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHD 412

Human   441 MACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVY--EDALGLG------- 496
            |||:|||::.:|......|....:|..|:.|||::...: ..|.|:.|:  ..:.|||
  Fly   413 MACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQAD-HPVHWSPVFVAGKSGGLGRDSEYQR 476

Human   497 -LVVTGTLPVFNLTQDGPGEKKNQLI-----LGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLN 555
             ||.|.:.|||        :::|..:     |||:|.||.:.:|:::.|.:.||.|||.|.:|.|
  Fly   477 RLVTTVSTPVF--------DRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNN 533

Human   556 GYVLLHPNLKP-----QTTNFREP--VTLDFLDAELED----ENKE----------EIRRSMIDG 599
            |.||.||:|:|     |..:..:|  .::|..:.||.:    .|.|          |:|..||..
  Fly   534 GRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKP 598

Human   600 NKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPI 664
            .:|..:...:....|.:.:...|..|.:.||..|.::|.:|||
  Fly   599 KEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLP---------------------- 641

Human   665 SKLKDFEFLLPSSFESEG-HVFIAPREYCKDLNASDNN-TEFLK---------------NFIELM 712
                          |..| |.|::.:|    :..|.|| ||:.|               |.:..:
  Fly   642 --------------EKYGSHEFVSQQE----IRHSRNNVTEYFKGDNWRVHPDWVYCEYNSVSDL 688

Human   713 EK----------------------------------------VTPDSKQ---------------- 721
            ||                                        |.|.|.|
  Fly   689 EKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPG 753

Human   722 ---------------------CNNFLLHNLILDTGITQQL-------------------VERVWR 746
                                 |:..||.:|:.|..:|..|                   :..:.:
  Fly   754 SSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILK 818

Human   747 DQDLNTYSLLAVFAATDGGITRVFPN-KAAEDWTENPEP---------FNASFYRRSLDNH---- 797
            .|....:.:...|.||..|:.|...: |..||   .|||         .:.|:|:|::|.|
  Fly   819 RQGYQKFVVATSFVATRSGLLRWIDHVKRPED---TPEPHFSEDNVRAMDTSWYKRAIDQHSVEP 880

Human   798 -GYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASN 861
             .:|:..|....    ..::::...:..|.|:.:..........|||::...::.|:.|..:.|
  Fly   881 DSFVYSVPFGSG----YAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITS- 940

Human   862 RTHQDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLA 926
                     .|...:.|:..|..:|.|  |.::|:.||:::|   .:.:..|:||.::|..:|.:
  Fly   941 ---------ACTGMTGCKRTCASDNLD--CYVLDNSGFVIIS---EEMEHTGKFFGQIDGTIMDS 991

Human   927 LYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLI 991
            |..:..|.|....|||..|:  ...|...|..|:..|.     .|..|       .|..||  .:
  Fly   992 LVQDRIYKRVTVNDYQGVCS--DADNPYTAAGGILKPN-----RLGSW-------FFNHLL--AL 1040

Human   992 YHSWFQADPAEAEGSPE---TRESSCVM-----KQTQYYFGSVNASYNAIID------------- 1035
            ..:|....||.....|:   |.::..|:     ...:|.||:.| .||..:|
  Fly  1041 SAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNEN-EYNMQVDQEMDEFFTTADVE 1104

Human  1036 --------------------------------------------------------C--GNCSRL 1042
                                                                    |  ..|.|.
  Fly  1105 YTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERP 1169

Human  1043 FHAQRLTNTNLLFVVAEKPLCSQC-----------EAGRLLQKETHSDGPEQCELVQRPRYRRGP 1096
            |..|::.::||:.:|.: .|| .|           |||.:....|...|.||       ..||.|
  Fly  1170 FSVQKIPHSNLILLVVD-TLC-PCGSKQLDIEPLEEAGVIGACSTRRQGQEQ-------ESRRRP 1225

Human  1097 HICFDYNATE-DTSDCGRGASFPPSLGVLVSLQLLLL 1132
            ..|.:|:..| :...||||::.....|.::...||::
  Fly  1226 KKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMV 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA2D2	XP_011532545.1	VWA_N	141..265	CDD:285584	37/133 (28%)
		vWA_VGCC_like	277..456	CDD:238740	68/182 (37%)
		Cache_1	485..573	CDD:280839	36/107 (34%)
		VGCC_alpha2	580..663	CDD:285647	19/96 (20%)
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	37/133 (28%)
		vWA_VGCC_like	245..428	CDD:238740	68/182 (37%)
		Cache_1	456..544	CDD:280839	34/95 (36%)
		VGCC_alpha2	590..>647	CDD:285647	17/92 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7302
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960