DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RPS6KA5 and rskn-2

DIOPT Version :9

Sequence 1:	NP_004746.2	Gene:	RPS6KA5 / 9252	HGNCID:	10434	Length:	802	Species:	Homo sapiens
Sequence 2:	NP_001348666.1	Gene:	rskn-2 / 172581	WormBaseID:	WBGene00008311	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	366/766 - (47%)
Similarity:	493/766 - (64%)	Gaps:	38/766 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    37 LTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
            |....|||.:|||.||:|||.|||||||||||:.|.|...:||||||:|..::.|.||.|||..|
Worm     5 LMPEGEKVSMENFALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAE 69

Human   102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
            |||||.:|.:||||.|.|||||:||||::::|:.||||||||..|..|.....:..:.|:|:|::
Worm    70 RQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDLEAARFVIAELVVAID 134

Human   167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSG 231
            .||:..:||||:||||||||..|||.||||||||.|:..|.:||.|:|||||||:|:::...:.|
Worm   135 SLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRPEGG 199

Human   232 HDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMK 296
            :...||||||||:.:|||||.|||||||.:||..:|::||:..:.|:|:.|...|:|.|.:||.|
Worm   200 YSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIAKRIMTKKVPFPKTMDVDARDFIGQLLEK 264

Human   297 DPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP 361
            ..:||||.  ...||||.|.|...|:||....:.:.....|.|..:||...|:.|||...|.|||
Worm   265 KLEKRLGY--NGVDEIKNHKFMSSIDWDAAVKRTLKPVIVPRIGHDLDTQFFSAEFTSQPPLYSP 327

Human   362 AALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLD 426
            |..|.::..||:|||:|:||::|..:..:.:.|.         ..:|  :|::..|.|:..|.||
Worm   328 AESPLNANTLFRGYSYVSPSVIFANDNVIGEELM---------AEDV--NALLASSSFFAKYKLD 381

Human   427 LKDKP-LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHD 490
            ..|.. ||:|:||:.|:|........|||||:|::..:..|:|...|::.:||||||:||:|..|
Worm   382 KSDAGLLGKGAFSVVRRCERVVDGAQFAVKIVSQKFASQAQREARILEMVQGHPNIVQLHDVHSD 446

Human   491 QLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDE 555
            .||.:||||:|.|.||.|||:|.:.|:|:||:.|||:|||||.::||..:|||||||||:||...
Worm   447 PLHFYLVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVKYLHDKRIVHRDLKPENILFESI 511

Human   556 NDNLEIKIIDFGFARLKPPD-NQPLK--------TPCFTLHYAAPELL----NQNGYDESCDLWS 607
            :.:..::::|||||||.|.. .|.||        ||||||.|||||:|    :|..|:|.|||||
Worm   512 DSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMTPCFTLQYAAPEVLDVGDSQPEYNEQCDLWS 576

Human   608 LGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDP 672
            |||:|:|||||||||.:..|.   .||.|||::|.:.:|||.|:||.|||.:||:||.|||||||
Worm   577 LGVVLFTMLSGQVPFHARSRQ---ESATEIMQRICRAEFSFTGDAWTNVSADAKNLITGLLTVDP 638

Human   673 NKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDK 737
            .|||.|..|..:.||:..:.:.: ||.||.||.||  |.:.....|..||....|:||.|.:|..
Worm   639 KKRLSMQELTAHMWLKSSASMDT-PLQTPSILPSS--AGNETFNETLRAFLHANRDGFHLLDVAA 700

Human   738 APLAKRRKMKKTSTSTETRSSSSESSHSS----SSHSHGKTTPTKTLQPSN 784
            |||.|||.:|:.|...:...:|..|..:.    ......:.| :.|.:|||
Worm   701 APLMKRRGIKRQSGDKDASGNSKNSRVTQFECLPEEQEAEMT-SSTSRPSN 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KA5	NP_004746.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		STKc_MSK1_N	48..337	CDD:270764	154/288 (53%)
		S_TK_X	320..379	CDD:214529	22/58 (38%)
		STKc_MSK1_C	418..727	CDD:271081	160/322 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..802		12/48 (25%)
rskn-2	NP_001348666.1	PKc_like	22..287	CDD:328722	147/266 (55%)
		S_TK_X	285..344	CDD:214529	22/58 (38%)
		STKc_MSK_C	374..694	CDD:270994	162/325 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161447972
Domainoid	1	1.000	309	1.000	Domainoid score	I801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48302
Inparanoid	1	1.050	679	1.000	Inparanoid score	I414
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52440
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0006452
OrthoInspector	1	1.000	-	-		otm15370
orthoMCL	1	0.900	-	-		OOG6_104032
Panther	1	1.100	-	-	O	PTHR24351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X3598
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940