Protein Alignment DHRS3 and Ldsdh1

DIOPT Version :10

• Sequence 1: NP_004744.2
• Gene: DHRS3 / 9249
• HGNCID: 17693
• Length: 302
• Species: Homo sapiens
• Sequence 2: NP_572436.1
• Gene: Ldsdh1 / 31726
• FlyBaseID: FBgn0029994
• Length: 320
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 88/293 - (30%)
• Similarity: 152/293 - (51%)
• Gaps: 11/293 - (3%)

Human     9 LVMFPLQMIYLVVK-------AAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKI 66
            :|:..:.::.|:||       |.|||.....|.|::.:.|||||.|.|:|:::|.::|:.|| .|
  Fly    22 IVLLVVDIVMLIVKFWLAIAEAIVGLFRAPPLDDVNGKVVLITGTGHGMGKEMALQYAKLGA-TI 85

Human    67 VLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKS 131
            :.|...|:...:|.:||:..|.:...::|:|..|||:.:.|:.||::.|.|.::||||.::....
  Fly    86 LCWDVNEQTNNQTVKEIKNNGGKAFGYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHP 150

Human   132 LMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAF 196
            |::..::.:.....||.|..||..:||||.|:|...|.||.|:|...|..:...:.||.:|.:..
  Fly   151 LLEHTENEIRLMYEINVLSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVR 215

Human   197 AFMESLTLGLLD---CPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQ 258
            .:|.:|...|..   ...|..||:.|:...|.:.:..|.||||||..:..:..|...:||.:...
  Fly   216 GYMAALVEELRQKNPQNNVKLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQRQGL 280

Human   259 ALLLLPWTMHALVILKSILPQAALEEIHKFSGT 291
            ....:|....|...:..::|:.|:..::.|..|
  Fly   281 EEAAIPRHFVAAEKIGRLIPRKAMRLVNDFFDT 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHRS3	NP_004744.2	17beta-HSDXI-like_SDR_c	53..281	CDD:187598	67/230 (29%)
Ldsdh1	NP_572436.1	Rossmann-fold NAD(P)(+)-binding proteins	60..287	CDD:473865	72/227 (32%)