DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR50 and mtnr1ba

DIOPT Version :9

Sequence 1:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_571470.1	Gene:	mtnr1ba / 30669	ZFINID:	ZDB-GENE-990415-157	Length:	355	Species:	Danio rerio

Alignment Length:	297	Identity:	147/297 - (49%)
Similarity:	217/297 - (73%)	Gaps:	3/297 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    25 PALIIFMFCAMVI-TIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHA 88
            ||.::.:...::| |.|||::||.:||::|.:|:||||:||.|||||:.||:||..|||||:|||
Zfish    28 PAWVVMVLAGVLIFTSVVDVLGNVLVIISVLRNRKLRNAGNAFVVSLAFADLLVVCYPYPLVLHA 92

Human    89 MSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITW 153
            |...||...:::|::.||:.|.||:||||||.||||||||:||.:..||:|:....|.:.|.:.|
Zfish    93 MLHAGWLPGEMECKVSGFLMGASVIGSIFNITAIAINRYCFICQANTYEKIYGRAGTLVLLTLVW 157

Human   154 IMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAA 218
            ::|.:|:|||:.:|::.||||.|:|.|:...:..:|:.:|.:||:||:.:|.|||:|||..||..
Zfish   158 VLTAIAILPNLSLGSLTYDPRVYSCTFSQTTSAGYTIAVVTVHFLLPIAVVTFCYLRIWVLVLRV 222

Human   219 RD--PAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYF 281
            |.  .....|..:.:|:|:||||||:|:||||||.|:|::.:.|||.|..:...:|:||::.:||
Zfish   223 RRRVTTDVRPRLRPSELRHFLTMFVVFVLFAVCWAPLNLIGLAVAVDPPRVGPLVPDWLFVMSYF 287

Human   282 IAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIF 318
            :||||||||||:|||||:||||||..|..::..|.:|
Zfish   288 MAYFNSCLNAVVYGLLNQNFRREYRRILLSLCKPRLF 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	79/158 (50%)
		7tm_1	45..294	CDD:278431	126/250 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438
		DUF4045	<364..600	CDD:289995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596
mtnr1ba	NP_571470.1	7tm_4	40..>145	CDD:304433	62/104 (60%)
mtnr1ba	NP_571470.1	7tm_1	49..300	CDD:278431	126/250 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387687at33208
OrthoFinder	1	1.000	-	-		FOG0001264
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920