DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR50 and srx-51

DIOPT Version :9

Sequence 1:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_506786.2	Gene:	srx-51 / 188398	WormBaseID:	WBGene00005942	Length:	310	Species:	Caenorhabditis elegans

Alignment Length:	294	Identity:	60/294 - (20%)
Similarity:	115/294 - (39%)	Gaps:	69/294 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    26 ALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMS 90
            ||.||...:      :.::.|..|.:.:.:...|:||..:...|.|:.|.:::.. :..::..|.
Worm     9 ALAIFSISS------IGVLANWTVAILIRRLPSLKNSFGMLTTSQSIGDAVISTI-FAFLIAPMC 66

Human    91 IGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIM 155
            ....:..:....::|.:..::...|.::.:.|::||:|.|...::||.|||:.||...:...|
Worm    67 FFNLEYLKTYSSVIGHVLIIAYEISTYSHLCISLNRFCAIVAPIKYENIFSIPNTNKLIAFFW-- 129

Human   156 TVLAVLPNMYIGTIEYDPRTYTC----IFNYLNNPV---------------FTVTIVCIHFVLPL 201
             ..|.||:.|: .:..|.:.|..    :|.:.:|||               ..::||.|.
Worm   130 -ASATLPSFYL-YVYNDCKFYFADIFWVFTFSDNPVCNTIAWYAGFLKYNSIVISIVIID----- 187

Human   202 LIVGFCYVRIW-TKVLAARDPAGQNPDNQLAEVRNFL---------------TMFVI-------- 242
             ::....||.: .||......:......::    |||               |.|:|
Worm   188 -VITVSKVRSYKAKVFGISTHSASKSSYEM----NFLKQACLQAFVFVCELVTYFLITPKMDPSE 247

Human   243 ----FLLFAVCWCPINVLTVLVAVS-PKEMAGKI 271
                |:|..|.|..::.|..::.:| .||....|
Worm   248 RWACFVLSTVAWISVHTLDGIITLSFNKEFTNTI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	37/177 (21%)
		7tm_1	45..294	CDD:278431	56/275 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438
		DUF4045	<364..600	CDD:289995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596
srx-51	NP_506786.2	TM helix 1	9..33	CDD:341315	6/29 (21%)
		7TM_GPCR_Srx	13..274	CDD:370981	54/281 (19%)
		TM helix 2	40..65	CDD:341315	3/25 (12%)
		TM helix 3	77..107	CDD:341315	6/29 (21%)
		TM helix 4	120..138	CDD:341315	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12412
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860