DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPR50 and npr-33

DIOPT Version :9

Sequence 1:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_510612.1	Gene:	npr-33 / 185141	WormBaseID:	WBGene00009278	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	74/310 - (23%)
Similarity:	137/310 - (44%)	Gaps:	35/310 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    10 PYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSG-NIFVVSLSVA 73
            |..|..|      :|....|......:|.|...:|||..::..:..::||.:|. |.|:::|::|
Worm    47 PLQCFSC------HPKLYFIVFGLVFMIIICAGVIGNIFIVFVILMDRKLMSSSVNQFLLNLAIA 105

Human    74 DMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYER 138
            |:...|:..|..:..:...||.|....|.::.|:....:..|:...:||.:.|:..||..::.:|
Worm   106 DLGNLIFCSPDAILVLIDRGWLLPNFACHLLRFLQEYFLYASVLLQMAIGVERFLAICSPMRMQR 170

Human   139 IFSVRNTCIYLVITWIMTVLAVLPN-MYIGTIEYDPRTYTCIFNYLNNPVFTVTIVC---IHFVL 199
             ||.:.|...|...|.:......|. :|.|.:.:  :.|.|.:..:::...|....|   :.:.:
Worm   171 -FSTKTTISVLAGVWCVAACFASPYFLYQGIVFH--KLYFCFWKGISHKTRTYFKYCELIVLYAI 232

Human   200 PLLIVGFCYVRIWTKVLAARDPAGQNPDNQ-----------LAEVRNFLTMFVI-FLLFAVCWCP 252
            ||:.:...| .|..:||..      |.||.           |...|:.:.|.:| .||:.:|:.|
Worm   233 PLVFLTTLY-SIMCRVLWG------NEDNHNIANHSQQEAILKLRRSVVKMLIISMLLYFLCYTP 290

Human   253 INVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFR 302
            |.||.:|..:....:  ::|.||.|....::..:|..|.::|.:...:||
Worm   291 IQVLFMLEKILDHSV--QLPQWLRLLLNVLSVMSSSTNPIVYIICCRHFR 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	38/163 (23%)
		7tm_1	45..294	CDD:278431	63/265 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438
		DUF4045	<364..600	CDD:289995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596
npr-33	NP_510612.1	7tm_classA_rhodopsin-like	62..332	CDD:381740	67/281 (24%)
		TM helix 1	62..86	CDD:381740	5/23 (22%)
		TM helix 2	96..118	CDD:381740	7/21 (33%)
		TM helix 3	134..156	CDD:381740	4/21 (19%)
		TM helix 4	178..194	CDD:381740	2/15 (13%)
		TM helix 5	219..242	CDD:381740	5/23 (22%)
		TM helix 6	271..296	CDD:381740	10/24 (42%)
		TM helix 7	309..332	CDD:381740	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010