Protein Alignment GCM2 and gcm2

DIOPT Version :10

• Sequence 1: NP_004743.1
• Gene: GCM2 / 9247
• HGNCID: 4198
• Length: 506
• Species: Homo sapiens
• Sequence 2: NP_001005603.1
• Gene: gcm2 / 449615
• ZFINID: ZDB-GENE-050127-1
• Length: 496
• Species: Danio rerio
• Alignment Length: 505
• Identity: 251/505 - (49%)
• Similarity: 326/505 - (64%)
• Gaps: 32/505 - (6%)

Human    12 VCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHI 76
            |||:||:|:||||||::||:...:|.|:||.|||||:||||::|.|||||||||||||||||..|
Zfish    14 VCSFGMKLTWDINDPKLPQDTKQYDAFQEWTDGYVRYIYSSEDKNAQRHLSGWAMRNTNNHNCQI 78

Human    77 LKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNF 141
            |||||||||||::.|:|||||:||||||||||||.|||||.||||:|||||||||||||||||||
Zfish    79 LKKSCLGVVVCSRNCSLPDGSKLQLRPAICDKARQKQQKKLCPNCNSALELIPCRGHSGYPVTNF 143

Human   142 WRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFS 206
            ||:||.|||||||||||||||||||||||||||:||:|:|....||:|:.|.|.....|.:  |.
Zfish   144 WRVDGKAIFFQAKGVHDHPRPESKSETEARRSAVKRRMSSPPFSQKRRLVEPEPGRYHDMA--FP 206

Human   207 NIPPL--ENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDL-ATFQGDKMPPFQKYSSPRIYL 268
            ||..|  |.||.|.|:.|::|||..|..|:|...:.||...|. |....|.....||.::.|:|:
Zfish   207 NIHQLTMEGPERFSIIAESNFPIQTQHYPTFQNPEPYKFPYDTHAAAMADAQSSLQKPANHRLYV 271

Human   269 PRPPCSYELANPGYTNSSPYP-TLYKDSTSIPNDTD----WVHLNTLQCNVNSYSSYERSF-DFT 327
            .||||.|:.|.|||..|.||| .||||.:|...:|:    ...|:.:....:...|:|||: :.:
Zfish   272 TRPPCGYDFAVPGYLGSGPYPAALYKDPSSPQMETEPNKSGSSLSGVSHGSSPLGSHERSYAESS 336

Human   328 NKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVSYQ 392
            .|.||||..|.|....:|.::.|....|...|||.:.||||.....|...||||:||||||||||
Zfish   337 GKHHGWKQILSKGGYGDRGDYSQLPTNANHHYYNSDYPCRYTGPAAPTPAALQTIITTTTKVSYQ 401

Human   393 -AYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRA 456
             ..:|..:||.:::.:||.||:||        |:..||           ||:....:||..|...
Zfish   402 PCPKPSVVKYGENIYDVKGLSNCN--------SILEEP-----------SPNSYSDLKIPEDSGV 447

Human   457 IRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF 506
            |:..::. .:.:.::.:.:|.::.......||.||.:|:...|.|::.::
Zfish   448 IKSALSY-QDTLPAKIERSENFEGYRYSSYSANSYPERMSHPFRYDSGEY 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCM2	NP_004743.1	GCM	35..172	CDD:397602	116/136 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..213		34/59 (58%)
		C-terminal conserved inhibitory domain (CCID). /evidence=ECO:0000269|PubMed:27745835	379..395		13/16 (81%)
gcm2	NP_001005603.1	GCM	37..174	CDD:397602	116/136 (85%)