Protein Alignment GCM2 and Gcm2

DIOPT Version :10

• Sequence 1: NP_004743.1
• Gene: GCM2 / 9247
• HGNCID: 4198
• Length: 506
• Species: Homo sapiens
• Sequence 2: NP_001099575.1
• Gene: Gcm2 / 291047
• RGDID: 1311127
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 345/506 - (68%)
• Similarity: 391/506 - (77%)
• Gaps: 2/506 - (0%)

Human     1 MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWA 65
            |||.::|:...|.||||:|:|||||||||||.|.||.|||||||||||||||.||||||||||||
  Rat     1 MPADSMQDPDPVLSYGMKLTWDINDPQMPQEPAHFDHFREWPDGYVRFIYSSQEKKAQRHLSGWA 65

Human    66 MRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPC 130
            ||||||||||||||||||||||.:||.|.|||.|||||||||||||||||||||||||||||:||
  Rat    66 MRNTNNHNGHILKKSCLGVVVCARACALKDGSHLQLRPAICDKARLKQQKKACPNCHSALELVPC 130

Human   131 RGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEA 195
            |||||||||||||||||||||||||||||||||||||||.||||:||||||||||||:|..|.||
  Rat   131 RGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEGRRSALKRQMASFYQPQKRRSEEPEA 195

Human   196 EENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQK 260
            ...||:.||.::.|..|..|.|.:..:|||||.|....|||.|||::.||||.||.||.:.||||
  Rat   196 GSTQDTRGHSNSTPVPEPSELFAMPADTSFPISGHSSLSFPNSDVHRVTCDLPTFPGDVILPFQK 260

Human   261 YSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFD 325
            ||:|.||.|.||.|||||:||.|.||||||||||.:.:|:|.||:|||:||.||:||.|||||.|
  Rat   261 YSNPSIYFPGPPWSYELASPGVTGSSPYPTLYKDPSIVPDDPDWIHLNSLQYNVSSYGSYERSLD 325

Human   326 FTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPPGAPALQTVITTTTKVS 390
            .|.:.|||||..||..|.|:.:....||:.|.||||.|||||||...|.|..|||||||||  |:
  Rat   326 LTARYHGWKPTHGKAGLEEKVDCRPCQAVPTSPYYNLELPCRYLPVAPAGTQALQTVITTT--VA 388

Human   391 YQAYQPPAMKYSDSVREVKSLSSCNYAPEDTGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCR 455
            |||||.||:|:.|||:||.||:||.||.|:..|.:||:...|.....:||||||..|..:.|||:
  Rat   389 YQAYQHPALKHGDSVQEVSSLASCTYASENLPMPIYPQALDPQEGAIQAASPSGRAPGIVPGDCQ 453

Human   456 AIRPTVAIPHEPVSSRTDEAETWDVCLSGLGSAVSYSDRVGPFFTYNNEDF 506
            |.|||:|.|.|...|||..|:.|||||||:||.::|.||.|..|..:||||
  Rat   454 AARPTLAFPQETDPSRTAGADVWDVCLSGVGSVMAYLDRTGQPFNLDNEDF 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCM2	NP_004743.1	GCM	35..172	CDD:397602	127/136 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..213		40/57 (70%)
		C-terminal conserved inhibitory domain (CCID). /evidence=ECO:0000269|PubMed:27745835	379..395		12/15 (80%)
Gcm2	NP_001099575.1	GCM	35..172	CDD:397602	127/136 (93%)